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Journal of Nutrition and Metabolism
Volume 2018, Article ID 9794629, 13 pages
https://doi.org/10.1155/2018/9794629
Research Article

The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through the Upregulation of Glutathione Synthesis

1Graduate Program Food Science and Technology, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil
2Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food Technology and Science, Centre of Rural Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil
3Graduate Program on Pharmacology, Centre of Health Sciences, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil
4Biogenomic Laboratory, Department of Morphology, Centre of Health Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil
5Department of Food Science, Federal University of Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil
6School of Food Engineering, University of Campinas, 13083-862 Campinas, SP, Brazil

Correspondence should be addressed to Tatiana Emanuelli; rb.msfu@illeuname.anaitat

Received 8 February 2018; Revised 24 May 2018; Accepted 31 May 2018; Published 1 August 2018

Academic Editor: José María Huerta

Copyright © 2018 Andréia Quatrin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. The aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance.