The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through the Upregulation of Glutathione Synthesis

Figure 2

Liver weight (a), serum level of TNF-α (b), serum transaminases activity (c), hepatic expression of caspase-3 (d), and hepatic expression of caspase-9 (e) in diabetic rats fed high-fat diet and treated with JPP or vehicle for 8 weeks (means ± SEM, ). Different from the control group. ^#Different from the diabetic-vehicle group (ALT, liver histology: ANOVA-Duncan’s test; liver weight: Kruskal–Wallis multiple comparison test; caspase-3 and caspase-9: ANOVA-Dunnett's test; ). The gene expression data were normalized by β-Actin gene. Mean ± SD were obtained from three independent repetitions. ALT: aspartate aminotransferase; AST: alanine aminotransferase; JPP: jaboticaba peel powder; TNF-α: tumour necrosis factor alfa.

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