Research Article

The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through the Upregulation of Glutathione Synthesis

Table 5

Effect of JPP treatment on the glycaemia, insulinemia, insulin sensitivity, and insulin resistance of control and diabetic rats.

ControlDiabetic
VehicleJPP-IJPP-IIJPP-III

Onset glucose (mg/dL)102.3 ± 1.5353.3 ± 29.9366.7 ± 20.6362.0 ± 16.7369.7 ± 42.2
End glucose (mg/dL)96.7 ± 1.9469.0 ± 15.6443.3 ± 20.1422.5 ± 15.1379.5 ± 36.4#
Insulin (mU/L)5.12 ± 0.67.39 ± 1.43.64 ± 0.7#10.10 ± 2.78.45 ± 2.5
QUICKI0.71 ± 0.020.46 ± 0.020.53 ± 0.02#0.44 ± 0.020.49 ± 0.03
FIRI0.56 ± 0.050.82 ± 0.090.58 ± 0.06#0.86 ± 0.080.79 ± 0.08

Glycaemia was assessed before (onset) and after (end) JPP treatment, whereas the other measures were only made after JPP treatment. Data are presented as means ± SEM (). Different from the control group. #Different from the diabetic-vehicle group (ANOVA followed by Duncan’s test, ). QUICKI: quantitative insulin sensitivity check index; FIRI: fasting insulin resistance index.