Research Article
CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy among Type 2 Diabetic Patients in Malaysia
Table 5
Hardy–Weinberg equilibrium test for the controls and cases.
| | SNP | Malays | Chinese | Indians | | Control | Statistic | Control | Statistic | Control | Statistic | | Major/major | Major/minor | Minor/minor | χ2 | value | df | Major/major | Major/minor | Minor/minor | χ2 | value | df | Major/major | Major/minor | Minor/minor | χ2 | value | df |
| | Control | | | CNDP1 | AA = 68 | CA = 25 | CC = 3 | 0.140 | 0.7083 | 1 | AA = 53 | CA = 34 | CC = 8 | 3.370 | 0.0664 | 1 | AA = 74 | CA = 37 | CC = 2 | 1.185 | 0.2763 | 1 | | rs2346061 | (70.8) | (26.0) | (3.1) | (55.8) | (35.8) | (8.4) | (65.5) | (32.7) | (1.8) | | CNDP1 | 5-5 = 6 | 6-5 = 33 | 6-6 = 57 | 0.171 | 0.6792 | 1 | 5-5 = 8 | 6-5 = 27 | 6-6 = 60 | 3.372 | 0.0663 | 1 | 5-5 = 21 | 6-5 = 76 | 6-6 = 39 | 2.574 | 0.1086 | 1 | | D18S880 | (6.2) | (34.4) | (59.4) | (8.4) | (28.4) | (63.2) | (15.4) | (55.9) | (28.7) | | MnSOD | CC = 73 | TC = 20 | TT = 3 | 1.168 | 0.2798 | 1 | CC = 74 | TC = 19 | TT = 2 | 0.439 | 0.5076 | 1 | CC = 102 | TC = 28 | TT = 5 | 2.740 | 0.0979 | 1 | | rs4880 | (76.0) | (20.8) | (3.2) | (77.9) | (20.0) | (2.1) | (75.6) | (20.7) | (3.7) | | NOS3 | GG = 71 | GT = 24 | TT = 1 | 0.439 | 0.5076 | 1 | GG = 71 | GT = 24 | TT = 1 | 1.904 | 0.1676 | 1 | GG = 101 | GT = 34 | TT = 2 | 0.206 | 0.6499 | 1 | | rs1799983 | (74.0) | (33.0) | (1.0) | (74.0) | (25.0) | (1.0) | (73.7) | (24.8) | (1.5) |
| | Case | | CNDP1 | AA = 87 | CA = 39 | CC = 5 | 0.057 | 0.8102 | 1 | AA = 61 | CA = 39 | CC = 5 | 0.152 | 0.6958 | 1 | AA = 33 | CA = 30 | CC = 4 | 0.697 | 0.4039 | 1 | | rs2346061 | (66.4) | (29.8) | (3.8) | (58.1) | (36.2) | (8.9) | (49.2) | (44.8) | (6.0) | | CNDP1 | 5-5 = 3 | 6-5 = 23 | 6-6 = 105 | 1.533 | 0.2156 | 1 | 5-5 = 3 | 6-5 = 21 | 6-6 = 94 | 1.749 | 0.1860 | 1 | 5-5 = 4 | 6-5 = 44 | 6-6 = 38 | 3.895 | 0.0484 | 1 | | D18S880 | (2.3) | (17.6) | (80.1) | (2.5) | (17.8) | (79.7) | (4.7) | (51.2) | (41.1) | | MnSOD | CC = 79 | TT = 45 | TT = 7 | 0.032 | 0.8582 | 1 | CC = 66 | TC = 37 | TT = 5 | 0.004 | 0.9490 | 1 | CC = 51 | TC = 29 | TT = 6 | 0.4373 | 0.5084 | 1 | | rs4880 | (60.3) | (34.3) | (5.4) | (61.1) | (34.3) | (4.6) | (59.3) | (33.7) | (5.8) | | NOS3 | GG = 74 | GT = 54 | TT = 3 | 3.668 | 0.0555 | 1 | GG = 60 | GT = 45 | TT = 3 | 0.9091 | 0.3404 | 1 | GG = 48 | GT = 35 | TT = 3 | 1.256 | 0.2625 | 1 | | rs1799983 | (56.5) | (41.2) | (2.3) | (55.6) | (41.7) | (2.7) | (58.8) | (40.7) | (3.5) |
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shows consistency with HWE. Genotype data are presented as a number of subjects (%). |
