Lugol Increases Lipolysis through Upregulation of PPAR-Gamma and Downregulation of C/EBP-Alpha in Mature 3T3-L1 Adipocytes

<div>Effect of lugol on lipolysis in mature 3T3-L1 adipocytes. Mature 3T3-L1 adipocytes were treated in the serum-free medium with 1–100 <i>µ</i>M of lugol for 0.5, 6, and 24 h. (a) Micrographs of cells stained with Oil Red O and quantification; (b) triglyceride content and (c) lipolytic activity were measured from the amount of glycerol in the culture medium. 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22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,55.606,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs control (vehicle) cells (<i>n</i> = 9). Scale bar is 100 <i>µ</i>m.</div>

Journal of Nutrition and Metabolism

fig2

Figure 2

Figure 2: Lugol Increases Lipolysis through Upregulation of PPAR-Gamma and Downregulation of C/EBP-Alpha in Mature 3T3-L1 Adipocytes 