Appropriate Timing and Type of Physical Training in Patients with COVID-19 for Muscle Health and Quality of Life: A Systematic Review
Table 1
Grade approach of eligible studies.
Certainty assessment
No. of patients
Effect
Certainty
Importance
No. of studies
Study design
Risk of bias
Inconsistency
Indirectness
Imprecision
Other considerations
Intervention
Comparison
Relative (95% CI)
Absolute (95% CI)
Mild acute COVID-19 (assessed with self-reported severity of respiratory symptoms development)
1
Observational studies
Seriousa
Seriousb
Not serious
Not serious
None
A total of 60 patients with COVID-19 who completed the full course of MRE were enrolled in this observational study. In total, 60 confirmed mild COVID-19 cases were enrolled with a median age of 54 years old. The baseline prevalence for dry cough, productive cough, difficulty in expectoration, and dyspnea were 41.7%, 43.3%, 35.0%, and 50.0%, respectively
⊕⊕◯◯ Low
Important
ICU condition (assessed with lung function, handgrip strength, and QOL)
3
Observational studies
Not seriousa
Seriousc
Not serious
Not serious
Strong association
All patient 93 admitted to ICU was in three studies was given intervention such as a regimented sequence of mobility, early rehabilitation and incentive breathing exercise. After following up the results showed improved of lung function and QOL, however no difference in hand grip strength
⊕⊕◯◯ Low
Important
Post-COVID-19 (assessed with 6 min walking test (6MWT), lung function, hand grip strength, and QOL questionnaire)
2
Randomized trials
Not serious
Not serious
Seriousc
Not serious
Strong association
All 196 participants post-COVID-19 were involved and received in two studies: 1) study one intervention group: a home-based 6-week exercise programme comprising breathing control and thoracic expansion, aerobic exercise, and LMS exercise; 2) study two received resistance training. The end of the trial show improved lung function, handgrip strength, 6 min walking test (6MWT), and QOL
