Table of Contents
Journal of Nanoparticles
Volume 2013, Article ID 370812, 9 pages
Research Article

Synthesis and Evaluation of Magnetic Nanoparticles for Biomedical Applications

1Department of Materials Science and Engineering, Tuskegee University, Tuskegee, AL 36088, USA
2Department of Pediatrics, Emory-Children's Center, Emory University, Atlanta, GA 30322, USA
3Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL 36104, USA

Received 24 October 2012; Revised 25 December 2012; Accepted 27 December 2012

Academic Editor: Fabien Grasset

Copyright © 2013 Nydeia W. Bolden et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this study, iron oxide (IO) nanoparticles from various precursors have been synthesized using sonochemical method and characterized for their structural variability and toxicity. The iron oxide (IO) precursor solutions were prepared from iron acetate (IA), iron pentacarbonyl (IP), decalin, PEG (poly(ethylene glycol)), EG (ethylene glycol), PVA (poly(vinyl alcohol)), β-cyclodextrin (CD), and distilled water. These precursor solutions were irradiated with high power ultrasound for 3 hours and heat treated as needed. These as-prepared iron oxide nanoparticles were characterized using X-ray diffraction (XRD), Mössbauer spectroscopy, transmission electron microscopy (TEM), and magnetization measurements. XRD results show that all the particles are highly crystalline in nature and the particles sizes measured from TEM are approximately 5–20 nm. The maximum magnetization was observed for IO-IP at approximately 60.17 emu/g and the minimum was approximately 30.56 emu/g for IO-IA. These results confirm that the particles are superparamagnetic (SPM) in nature. Mössbauer spectroscopy verified the magnetic nanoparticles are purely Fe3O4 and particles sizes varied by the nature of the precursor and coatings.