Table of Contents
Journal of Nanoparticles
Volume 2016, Article ID 6309231, 18 pages
http://dx.doi.org/10.1155/2016/6309231
Research Article

A Thermofluid Analysis of the Magnetic Nanoparticles Enhanced Heating Effects in Tissues Embedded with Large Blood Vessel during Magnetic Fluid Hyperthermia

Department of Mechanical Engineering, Future Institute of Engineering and Management, Sonarpur Station Road, Kolkata 700150, India

Received 14 October 2015; Revised 1 March 2016; Accepted 8 March 2016

Academic Editor: You Qiang

Copyright © 2016 Koustov Adhikary and Moloy Banerjee. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The thermal effect developed due to the heating of magnetic nanoparticles (MNPs) in presence of external magnetic field can be precisely controlled by the proper selection of magnetic absorption properties of the MNPs. The present paper deals with the numerical simulation of temperature field developed within or outside the tumor, in the presence of an external alternating magnetic field, using a thermofluidic model developed using ANSYS FLUENT®. A three-layer nonuniform tissue structure with one or two blood vessels surrounding the tumor is considered for the present simulation. The results obtained clearly suggest that the volumetric distribution pattern of MNPs within the tumor has a strong influence on the temperature field developed. The linear pattern of volumetric distribution has a strong effect over the two other types of distribution considered herein. Various other important factors like external magnetic field intensity, frequency, vascular congestion, types of MNP material, and so forth are considered to find the influence on the temperature within the tumor. Results show that proper selection of these parameters has a strong influence on the desired therapeutic temperature range and thus it is of utmost importance from the efficacy point of view of magnetic fluid hyperthermia (MFH).