Table of Contents
Journal of Nanoscience
Volume 2014, Article ID 201482, 8 pages
http://dx.doi.org/10.1155/2014/201482
Research Article

Comparative Study on the Synergistic Action of Differentially Synthesized Silver Nanoparticles with β-Cephem Antibiotics and Chloramphenicol

1Centre for Nanoscience and Nanotechnology, University of Kerala, Kariavattom Campus, Thiruvananthapuram, Kerala 695581, India
2Department of Biotechnology, University of Kerala, Kariavattom Campus, Thiruvananthapuram, Kerala 695581, India

Received 31 July 2014; Revised 27 October 2014; Accepted 27 October 2014; Published 13 November 2014

Academic Editor: Mingwang Shao

Copyright © 2014 Neethu Hari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Synergistic activity of cephem antibiotics with silver nanoparticles (Ag NPs) was investigated. Silver nanoparticles were synthesized through biological and chemical method. The combined action of β-lactam cephem antibiotics with both green and chemically synthesized silver nanoparticles enhances the antibacterial activity against wide range of antibiotic resistant pathogens and making them applicable to medical devices and microbial control systems. Synergistic activity of chloramphenicol with silver nanoparticles was also studied.