Research Article
Formulation of a Novel Nanoemulsion System for Enhanced Solubility of a Sparingly Water Soluble Antibiotic, Clarithromycin
Table 2
Experimental setup for 20 experiments.
| | Std. run | Olive oil (L) | Polysorbate 80 (L) | PVA (%) | | Coded | Actual | Coded | Actual | Coded | Actual |
| | 1 | −1.000 | 5 | −1.000 | 500 | −1.000 | 0.1 | | 2 | 1.000 | 500 | −1.000 | 500 | −1.000 | 0.1 | | 3 | −1.000 | 5 | 1.000 | 1500 | −1.000 | 0.1 | | 4 | 1.000 | 500 | 1.000 | 1500 | −1.000 | 0.1 | | 5 | −1.000 | 5 | −1.000 | 500 | 1.000 | 1 | | 6 | 1.000 | 500 | −1.000 | 500 | 1.000 | 1 | | 7 | −1.000 | 5 | 1.000 | 1500 | 1.000 | 1 | | 8 | 1.000 | 500 | 1.000 | 1500 | 1.000 | 1 | | 9 | −1.682 | −163.744 | 0.000 | 1000 | 0.000 | 0.55 | | 10 | 1.682 | 668.7437 | 0.000 | 1000 | 0.000 | 0.55 | | 11 | 0.000 | 252.5 | −1.682 | 159.1036 | 0.000 | 0.55 | | 12 | 0.000 | 252.5 | 1.682 | 1840.896 | 0.000 | 0.55 | | 13 | 0.000 | 252.5 | 0.000 | 1000 | −1.682 | −0.20681 | | 14 | 0.000 | 252.5 | 0.000 | 1000 | 1.682 | 1.306807 | | 15 | 0.000 | 252.5 | 0.000 | 1000 | 0.000 | 0.55 | | 16 | 0.000 | 252.5 | 0.000 | 1000 | 0.000 | 0.55 | | 17 | 0.000 | 252.5 | 0.000 | 1000 | 0.000 | 0.55 | | 18 | 0.000 | 252.5 | 0.000 | 1000 | 0.000 | 0.55 | | 19 | 0.000 | 252.5 | 0.000 | 1000 | 0.000 | 0.55 | | 20 | 0.000 | 252.5 | 0.000 | 1000 | 0.000 | 0.55 |
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