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Research Letters in Nanotechnology
Volume 2008 (2008), Article ID 527294, 4 pages
Research Letter

Assembly/Disassembly of DNA-Au Nanoparticles: A Strategy of Intervention

1Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902-6000, USA
2Department of Biological Sciences, State University of New York at Binghamton, Binghamton, NY 13902-6000, USA

Received 24 December 2007; Accepted 19 January 2008

Academic Editor: Yoke Khin Yap

Copyright © 2008 I-Im S. Lim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This report describes the viability of a strategy for manipulating the assembly/disassembly processes of DNA-Au nanoparticles by molecular intervention. Using the temperature-induced assembly and disassembly processes of DNAs and gold nanoparticles as a model system, the introduction of a molecular recognition probe is demonstrated to lead to the intervention of the assembly/disassembly processes depending on its specific biorecognition. This process can be detected by monitoring the change in the optical properties of gold nanoparticles and their DNA assemblies. Implications of the preliminary results to exploration of the resulting nanostructures for fine-tuning of the interfacial reactivities in DNA-based bioassays and biomaterial engineering are also discussed.