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Journal of Nanotechnology
Volume 2012, Article ID 971380, 15 pages
Review Article

Surface-Enhanced Raman Scattering as an Emerging Characterization and Detection Technique

1Department of Genetics and Bioengineering, Yeditepe University, Atasehir, Kadıkoy, 34755 Istanbul, Turkey
2Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
3Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA

Received 3 March 2012; Accepted 27 April 2012

Academic Editor: Simion Astilean

Copyright © 2012 Mustafa Culha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


While surface-enhanced Raman spectroscopy (SERS) has been attracting a continuously increasing interest of scientific community since its discovery, it has enjoyed a particularly rapid growth in the last decade. Most notable recent advances in SERS include novel technological approaches to SERS substrates and innovative applications of SERS in medicine and molecular biology. While a number of excellent reviews devoted to SERS appeared in the literature over the last two decades, we will focus this paper more specifically on several promising trends that have been highlighted less frequently. In particular, we will briefly overview strategies in designing and fabricating SERS substrates using deterministic patterning and then cover most recent biological applications of SERS.