Amino-Functionalized Silica Nanoparticles: In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer

Figure 1

Schematic diagram showing the synthesis of amino-functionalized SiNPs encapsulating doxorubicin conjugated with anti-Claudin-4. Anti-CLN4: anti-Claudin-4; APTES: 3-aminopropyl triethoxysilane; EDC: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; TEOS: tetraethyl ortho-silicate.