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Journal of Nanotechnology
Volume 2016, Article ID 7051523, 6 pages
Research Article

Release of siRNA from Liposomes Induced by Curcumin

1Department of Food and Nutrition, Faculty of Human Life Science, Senri Kinran University, Fujishirodai, Suita City, Osaka, Japan
2R&D Division, Katayama Chemical Industries, Co., Ltd., Ina, Minoh City, Osaka, Japan
3Department of Bioengineering Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya City, Aichi, Japan
4Department of Biomolecular Science and Reaction, The Institute of Scientific and Industrial Research (Sanken), Osaka University, Ibaraki City, Osaka, Japan
5Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama City, Okayama, Japan

Received 8 June 2016; Accepted 20 October 2016

Academic Editor: María J. Lázaro

Copyright © 2016 Kazuyo Fujita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin. Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin. About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions. Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA.