Clinical Study
CYP1A1, mEH, and GSTM1 Polymophisms and Risk of Oral and Pharyngeal Cancer: A Spanish Case-Control Study
Table 3
Risks for the different polymorphisms broken down by
smoking categories.
| | Genetic polymorphism | Cases | Controls | OR crude | OR adjusted |
| | Light/moderate
smokers (≤35 pack-years) |
| | CYP1A1 | | | | |
| | No mutated | 28 | 41 | 1.00 | 1.00 | | Mutated | 1 | 2 | 0.76 (0.06–8.90) | 1.12 (0.09–13.94) |
| | mEH (139) | | | | |
| | His/His | 20 | 58 | 1.00 | 1,00 | | His/Arg | 8 | 24 | 1.06 (0.40–2.78) | 1.08 (0.37–3.13) | | Arg/arg | 1 | 1 | 1.91 (0.11–33.10) | 2.82 (0.15–52.41) |
| | GSTM1 | | | | |
| | Present | 17 | 43 | 1.00 | 1.00 | | Absent | 12 | 40 | 0.74 (0.31–1.76) | 0.88 (0.34–2.34) |
| | Heavy smokers
(>35 pack-years) |
| | CYP1A1 | | | | |
| | No mutated | 23 | 62 | 1.00 | 1.00 | | Mutated | 0 | 1 | — | — |
| | mEH (139) | | | | |
| | His/His | 43 | 30 | 1.00 | 1.00 | | His/Arg | 17 | 17 | 0.94 (0.39–2.26) | 0.68 (0.25–1.86) | | Arg/arg | 3 | 0 | — | — |
| | GSTM1 | | | | |
| | Present | 28 | 25 | 1.00 | 1.00 | | Absent | 35 | 22 | 1.50 (0.67–1.33) | 1.40 (0.57–3.43) |
|
|
