Journal of Oncology / 2008 / Article / Tab 2

Research Article

Radiation Therapy in Addition to Gross Total Resection of Retroperitoneal Sarcoma Results in Prolonged Survival: Results from a Single Institutional Study

Table 2

Patient, tumor, and treatment characteristics.

Parameters Preoperative EBRT group Postoperative EBRT group P value

Gender

Female12 (63%)8 (67%) 1.00
Male7 (37%)4 (33%)

Age at presentation

≤50 years8 (42%)2 (17%) .24
>50 years11 (58%)10 (83%)

AJCC stage

I5 (26%)5 (42%) .24
III12 (63%)3 (25%)
IV2 (11%)2 (17%)

Grade

13 (16%)3 (25%) .66
24 (21%)2 (17%)
312 (63%)5 (42%)

Tumor size

10 cm7 (37%)9 (75%) .07
10 cm12 (63%)3 (25%)

Lesion presentation

Primary17 (89%)7 (58%) .08
Recurrent2 (11%)5 (42%)

Histology

Leiomyosarcoma9 (47%)6 (50%) .72
Liposarcoma7 (37%)3 (25%)
Other3 (16%)3 (25%)

Extent resection

STR4 (21%)1 (8%) .62
GTR15 (79%)11 (92%)

Organs removed

No9 (47%)3 (25%) .27
Yes10 (53%)9 (75%)

Chemo

No16 (84%)9 (75%) .65
Yes3 (16%)3 (25%)

IORT

No6 (32%)9 (75%) .03
Yes (1 pt each arm had 2 fields)13 (68%)3 (25%)

Radiotherapy dose

EBRT median (range)59.4 Gy (36.8–63.4 Gy)59.4 Gy (54–68.4) .79
IORT median (range)11 Gy (10–12 Gy)11 Gy (10–12 Gy)

IMRT

No17 (89%)4 (33%) .002
Yes2 (11%)8 (67%)

Time to complete EBRT Median (range)45 days (17–90 days)44 days (41–55 days) .76

Length of F/U Median (range)22 months (0.6–56.5 months)13.05 months (1.4–66.4 months) .55

EBRT = external beam radiation therapy; STR = subtotal resection; GTR = gross total resection; IORT = intraoperative radiation therapy; IMRT = intensity modulated radiation therapy; F/U = follow-up.

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