Table of Contents Author Guidelines Submit a Manuscript
Journal of Oncology
Volume 2008, Article ID 907892, 7 pages
http://dx.doi.org/10.1155/2008/907892
Review Article

New Pathways for Alimentary Mucositis

1Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
2Division of Medicine, The University of Adelaide, Adelaide, SA 5000, Australia
3Mucositis Research Laboratory, Hanson Institute, Frome Rd, Adelaide, South Australia 5000, Australia

Received 19 June 2008; Accepted 12 August 2008

Academic Editor: James Mulshine

Copyright © 2008 Joanne M. Bowen and Dorothy M. K. Keefe. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. S. Herbst, “Toxicities of antiangiogenic therapy in non-small-cell lung cancer,” Clinical Lung Cancer, vol. 8, pp. S23–S30, 2006. View at Google Scholar
  2. S. T. Sonis, R. Haddad, M. Posner et al., “Gene expression changes in peripheral blood cells provide insight into the biological mechanisms associated with regimen-related toxicities in patients being treated for head and neck cancers,” Oral Oncology, vol. 43, no. 3, pp. 289–300, 2007. View at Publisher · View at Google Scholar · View at PubMed
  3. J. M. Bowen, R. J. Gibson, A. Tsykin, A. M. Stringer, R. M. Logan, and D. M. K. Keefe, “Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy,” International Journal of Cancer, vol. 121, no. 8, pp. 1847–1856, 2007. View at Publisher · View at Google Scholar · View at PubMed
  4. D. M. K. Keefe, “Gastrointestinal mucositis: a new biological model,” Supportive Care in Cancer, vol. 12, no. 1, pp. 6–9, 2004. View at Publisher · View at Google Scholar · View at PubMed
  5. D. M. K. Keefe, J. Brealey, G. J. Goland, and A. G. Cummins, “Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans,” Gut, vol. 47, no. 5, pp. 632–637, 2000. View at Publisher · View at Google Scholar
  6. D. M. K. Keefe, D. E. Peterson, and M. M. Schubert, “Developing evidence-based guidelines for management of alimentary mucositis: process and pitfalls,” Supportive Care in Cancer, vol. 14, no. 6, pp. 492–498, 2006. View at Publisher · View at Google Scholar · View at PubMed
  7. D. M. K. Keefe, R. J. Gibson, and M. Hauer-Jensen, “Gastrointestinal mucositis,” Seminars in Oncology Nursing, vol. 20, no. 1, pp. 38–47, 2004. View at Publisher · View at Google Scholar
  8. J.-L. Pico, A. Avila-Garavito, and P. Naccache, “Mucositis: its occurrence, consequences, and treatment in the oncology setting,” The Oncologist, vol. 3, no. 6, pp. 446–451, 1998. View at Google Scholar
  9. D. M. F. Savarese, C.-C. Hsieh, and F. M. Stewart, “Clinical impact of chemotherapy dose escalation in patients with hematologic malignancies and solid tumors,” Journal of Clinical Oncology, vol. 15, no. 8, pp. 2981–2995, 1997. View at Google Scholar
  10. C. Scully, S. T. Sonis, and P. D. Diz, “Oral mucositis,” Oral Diseases, vol. 12, no. 3, pp. 229–241, 2006. View at Publisher · View at Google Scholar · View at PubMed
  11. S. R. Fanning, L. Rybicki, M. Kalaycio et al., “Severe mucositis is associated with reduced survival after autologous stem cell transplantation for lymphoid malignancies,” British Journal of Haematology, vol. 135, no. 3, pp. 374–381, 2006. View at Publisher · View at Google Scholar · View at PubMed
  12. L. S. Elting, C. Cooksley, M. Chambers, S. B. Cantor, E. Manzullo, and E. B. Rubenstein, “The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis,” Cancer, vol. 98, no. 7, pp. 1531–1539, 2003. View at Publisher · View at Google Scholar · View at PubMed
  13. L. S. Elting, C. D. Cooksley, M. S. Chambers, and A. S. Garden, “Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies,” International Journal of Radiation Oncology, Biology, Physics, vol. 68, no. 4, pp. 1110–1120, 2007. View at Publisher · View at Google Scholar · View at PubMed
  14. R. V. Lalla, M. M. Schubert, R.-J. Bensadoun, and D. M. K. Keefe, “Anti-inflammatory agents in the management of alimentary mucositis,” Supportive Care in Cancer, vol. 14, no. 6, pp. 558–565, 2006. View at Publisher · View at Google Scholar · View at PubMed
  15. S. T. Sonis, “The pathobiology of mucositis,” Nature Reviews Cancer, vol. 4, no. 4, pp. 277–284, 2004. View at Publisher · View at Google Scholar · View at PubMed
  16. S. T. Sonis, “Pathobiology of oral mucositis: novel insights and opportunities,” The Journal of Supportive Oncology, vol. 5, no. 9, supplement 4, pp. 3–11, 2007. View at Google Scholar
  17. C. S. Potten, “The cell kinetic mechanism for radiation-induced cellular depletion of epithelial tissue based on hierarchical differences in radiosensitivity,” International Journal of Radiation Biology, vol. 40, no. 2, pp. 217–225, 1981. View at Publisher · View at Google Scholar
  18. P. Stiff, “Mucositis associated with stem cell transplantation: current status and innovative approaches to management,” Bone Marrow Transplantation, vol. 27, pp. S3–S11, 2001. View at Google Scholar
  19. F. Paris, Z. Fuks, A. Kang et al., “Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice,” Science, vol. 293, no. 5528, pp. 293–297, 2001. View at Publisher · View at Google Scholar · View at PubMed
  20. P. Niscola, C. Romani, L. Cupelli et al., “Mucositis in patients with hematologic malignancies: an overview,” Haematologica, vol. 92, no. 2, pp. 222–231, 2007. View at Publisher · View at Google Scholar
  21. S. T. Sonis, “A biological approach to mucositis,” The Journal of Supportive Oncology, vol. 2, no. 1, pp. 21–32, 2004. View at Google Scholar
  22. S. T. Sonis, L. S. Elting, D. M. K. Keefe et al., “Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients,” Cancer, vol. 100, no. S9, pp. 1995–2025, 2004. View at Publisher · View at Google Scholar · View at PubMed
  23. S. T. Sonis, “Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity,” Oral Oncology, vol. 34, no. 1, pp. 39–43, 1998. View at Publisher · View at Google Scholar
  24. S. T. Sonis, “Pathobiology of mucositis,” Seminars in Oncology Nursing, vol. 20, no. 1, pp. 11–15, 2004. View at Publisher · View at Google Scholar
  25. S. T. Sonis and E. G. Fey, “Oral complications of cancer therapy,” Oncology, vol. 16, no. 5, pp. 680–686, 2002. View at Google Scholar
  26. S. T. Sonis, J. Scherer, S. Phelan et al., “The gene expression sequence of radiated mucosa in an animal mucositis model,” Cell Proliferation, vol. 35, pp. 93–102, 2002. View at Publisher · View at Google Scholar
  27. R. M. Logan, R. J. Gibson, J. M. Bowen, A. M. Stringer, S. T. Sonis, and D. M. K. Keefe, “Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis,” Cancer Chemotherapy and Pharmacology, vol. 62, no. 1, pp. 33–41, 2008. View at Publisher · View at Google Scholar · View at PubMed
  28. R. M. Logan, A. M. Stringer, J. M. Bowen, R. J. Gibson, S. T. Sonis, and D. M. K. Keefe, “Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?,” Cancer Chemotherapy and Pharmacology. In press. View at Publisher · View at Google Scholar · View at PubMed
  29. J. Leblond, F. Le Pessot, A. Hubert-Buron et al., “Chemotherapy-induced mucositis is associated with changes in proteolytic pathways,” Experimental Biology and Medicine, vol. 233, no. 2, pp. 219–228, 2008. View at Publisher · View at Google Scholar · View at PubMed
  30. B. van't Land, N. M. A. Blijlevens, J. Marteijn et al., “Role of curcumin and the inhibition of NF-κB in the onset of chemotherapy-induced mucosal barrier injury,” Leukemia, vol. 18, no. 2, pp. 276–284, 2004. View at Publisher · View at Google Scholar · View at PubMed
  31. J. Zhao, L. Huang, N. Belmar, R. Buelow, and T. Fong, “Oral RDP58 allows CPT-11 dose intensification for enhanced tumor response by decreasing gastrointestinal toxicity,” Clinical Cancer Research, vol. 10, no. 8, pp. 2851–2859, 2004. View at Publisher · View at Google Scholar
  32. L. Anthony, J. M. Bowen, A. Garden, I. Hewson, and S. T. Sonis, “New thoughts on the pathobiology of regimen-related mucosal injury,” Supportive Care in Cancer, vol. 14, no. 6, pp. 516–518, 2006. View at Publisher · View at Google Scholar · View at PubMed
  33. A. Barasch and D. E. Peterson, “Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions,” Oral Oncology, vol. 39, no. 2, pp. 91–100, 2003. View at Publisher · View at Google Scholar
  34. C. R. Miller and H. L. McLeod, “Pharmacogenomics of cancer chemotherapy-induced toxicity,” The Journal of Supportive Oncology, vol. 5, no. 1, pp. 9–14, 2007. View at Google Scholar
  35. K. Robien, M. M. Schubert, B. Bruemmer, M. E. Lloid, J. D. Potter, and C. M. Ulrich, “Predictors of oral mucositis in patients receiving hematopoietic cell transplants for chronic myelogenous leukemia,” Journal of Clinical Oncology, vol. 22, no. 7, pp. 1268–1275, 2004. View at Publisher · View at Google Scholar · View at PubMed
  36. C. M. Ulrich, Y. Yasui, R. Storb et al., “Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism,” Blood, vol. 98, no. 1, pp. 231–234, 2001. View at Publisher · View at Google Scholar
  37. K. Bogunia-Kubik, M. Polak, and A. Lange, “TNF polymorphisms are associated with toxic but not with aGVHD complications in the recipients of allogeneic sibling haematopoietic stem cell transplantation,” Bone Marrow Transplantation, vol. 32, no. 6, pp. 617–622, 2003. View at Publisher · View at Google Scholar · View at PubMed
  38. K. Sakamoto, M. Oka, S. Yoshino et al., “Relation between cytokine promoter gene polymorphism and toxicity of 5-fluorouracil plus cisplatin chemotherapy,” Oncology Reports, vol. 16, no. 2, pp. 381–387, 2006. View at Google Scholar
  39. G. Aprile, M. Ramoni, D. M. K. Keefe, and S. T. Sonis, “Application of distance matrices to define associations between acute toxicities in colorectal cancer patients receiving chemotherapy,” Cancer, vol. 112, no. 2, pp. 284–292, 2008. View at Publisher · View at Google Scholar · View at PubMed
  40. G. Aprile, M. Ramoni, D. M. K. Keefe, and S. T. Sonis, “Network analyses to define chemotherapy toxicity clusters in patients with colorectal cancer (CRC),” Journal of Clinical Oncology, vol. 25, no. 18S, p. 9045, 2007. View at Google Scholar
  41. S. T. Sonis, “The biologic role for nuclear factor-κB in disease and its potential involvement in mucosal injury associated with anti-neoplastic therapy,” Critical Reviews in Oral Biology and Medicine, vol. 13, no. 5, pp. 380–389, 2002. View at Google Scholar
  42. R. Pandey, R. K. Guru, and D. W. Mount, “Pathway Miner: extracting gene association networks from molecular pathways for predicting the biological significance of gene expression microarray data,” Bioinformatics, vol. 20, no. 13, pp. 2156–2158, 2004. View at Publisher · View at Google Scholar · View at PubMed
  43. H. V. Worthington, J. E. Clarkson, and O. B. Eden, “Interventions for preventing oral mucositis for patients with cancer receiving treatment,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD000978, 2007. View at Publisher · View at Google Scholar · View at PubMed
  44. D. M. K. Keefe, M. M. Schubert, L. S. Elting et al., “Updated clinical practice guidelines for the prevention and treatment of mucositis,” Cancer, vol. 109, no. 5, pp. 820–831, 2007. View at Publisher · View at Google Scholar · View at PubMed
  45. M. R. Posner and R. I. Haddad, “Novel agents for the treatment of mucositis,” The Journal of Supportive Oncology, vol. 5, no. 9, supplement 4, pp. 33–39, 2007. View at Google Scholar
  46. D. M. K. Keefe, “Intestinal mucositis: mechanisms and management,” Current Opinion in Oncology, vol. 19, no. 4, pp. 323–327, 2007. View at Publisher · View at Google Scholar · View at PubMed
  47. F. Chiappelli, “The molecular immunology of mucositis: implications for evidence-based research in alternative and complementary palliative treatments,” Evidence-Based Complementary and Alternative Medicine, vol. 2, no. 4, pp. 489–494, 2005. View at Publisher · View at Google Scholar · View at PubMed
  48. L. E. Volpato, T. C. Silva, T. M. Oliveira, V. T. Sakai, and M. A. Machado, “Radiation therapy and chemotherapy-induced oral mucositis,” Revista Brasileira de Otorrinolaringologia, vol. 73, no. 4, pp. 562–568, 2007. View at Google Scholar
  49. D. M. K. Keefe, J. Lees, and N. Horvath, “Palifermin for oral mucositis in the high-dose chemotherapy and stem cell transplant setting: the Royal Adelaide Hospital Cancer Centre experience,” Supportive Care in Cancer, vol. 14, no. 6, pp. 580–582, 2006. View at Publisher · View at Google Scholar · View at PubMed
  50. N. Blijlevens and S. T. Sonis, “Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis,” Annals of Oncology, vol. 18, no. 5, pp. 817–826, 2007. View at Publisher · View at Google Scholar · View at PubMed
  51. W. E. Evans, “Pharmacogenomics: marshalling the human genome to individualise drug therapy,” Gut, vol. 52, pp. ii10–ii18, 2003. View at Publisher · View at Google Scholar
  52. W. E. Evans and H. L. McLeod, “Pharmacogenomics—drug disposition, drug targets, and side effects,” The New England Journal of Medicine, vol. 348, no. 6, pp. 538–549, 2003. View at Publisher · View at Google Scholar · View at PubMed
  53. I. J. Buño, J. C. Huff, W. L. Weston, D. T. Cook, and S. L. Brice, “Elevated levels of interferon gamma, tumor necrosis factor α, interleukins 2, 4, and 5, but not interleukin 10, are present in recurrent aphthous stomatitis,” Archives of Dermatology, vol. 134, no. 7, pp. 827–831, 1998. View at Publisher · View at Google Scholar
  54. A. L. S. Guimarães, J. de F. Correia-Silva, A. R. de Sá et al., “Investigation of functional gene polymorphisms IL-1β, IL-6, IL-10 and TNF-α in individuals with recurrent aphthous stomatitis,” Archives of Oral Biology, vol. 52, no. 3, pp. 268–272, 2007. View at Publisher · View at Google Scholar · View at PubMed