Table of Contents Author Guidelines Submit a Manuscript
Journal of Oncology
Volume 2009 (2009), Article ID 247873, 4 pages
http://dx.doi.org/10.1155/2009/247873
Case Report

Antiangiogenic Therapy in the Treatment of Recurrent Medulloblastoma in the Adult: Case Report and Review of the Literature

U.O. Radiodiagnostica e Radioterapia Oncologica, AOU Policlinico “G. Rodolico”—Catania, Via Santa Sofia 78-95125—Catania, Italy

Received 27 May 2009; Revised 9 August 2009; Accepted 3 November 2009

Academic Editor: David Ball

Copyright © 2009 Giuseppe Privitera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. CBTRUS Executive Team Central Brain Tumor Registry of the United States, “Primary brain tumors in the United States, 1992–1997,” Statistical Report, CBTRUS, Chicago, Ill, USA, 2000. View at Google Scholar
  2. G. S. Bauman, P. K. Sneed, W. M. Wara et al., “Reirradiation of primary CNS tumors,” International Journal of Radiation Oncology Biology Physics, vol. 36, no. 2, pp. 433–441, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. M. T. Giordana, P. Cavalla, A. Dutto, L. Borsotti, A. Chiò, and D. Schiffer, “Is medulloblastoma the same tumor in children and adults?” Journal of Neuro-Oncology, vol. 35, no. 2, pp. 169–176, 1997. View at Google Scholar
  4. U. Herrlinger, A. Steinbrecher, J. Rieger et al., “Adult medulloblastoma: prognostic factors and response to therapy at diagnosis and at relapse,” Journal of Neurology, vol. 252, no. 3, pp. 291–299, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. R. Taylor, C. L. Bailey, and K. Robinson, “Results of randomized study of pre-radiation chemotherapy vs radiotherapy alone for non metastatic (M0-1) medulloblastoma: the SIOP UKCCSG PNET study,” Journal of Clinical Oncology, vol. 21, pp. 1581–1591, 2003. View at Google Scholar
  6. R. J. Packer, L. N. Sutton, R. Elterman et al., “Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy,” Journal of Neurosurgery, vol. 81, no. 5, pp. 690–698, 1994. View at Google Scholar
  7. D. M. Tait, H. Thornton-Jones, H. J. G. Bloom, J. Lemerle, and P. Morris-Jones, “Adjuvant chemotherapy for medulloblastoma: the first multi-centre control trial of the International Society of Paediatric Oncology (SIOP I),” European Journal of Cancer, vol. 26, no. 4, pp. 464–469, 1990. View at Google Scholar
  8. A. E. Evans, R. D. T. Jenkin, R. Sposto et al., “The treatment of medulloblastoma. Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone,” Journal of Neurosurgery, vol. 72, no. 4, pp. 572–582, 1990. View at Google Scholar
  9. R. J. Packer, L. N. Sutton, J. W. Goldwein et al., “Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma,” Journal of Neurosurgery, vol. 74, no. 3, pp. 433–440, 1991. View at Google Scholar
  10. R.-D. Kortmann, J. Kühl, B. Timmermann et al., “Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT '91,” International Journal of Radiation Oncology Biology Physics, vol. 46, no. 2, pp. 269–279, 2000. View at Publisher · View at Google Scholar
  11. P. M. Zeltzer, J. M. Boyett, J. L. Finlay et al., “Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study,” Journal of Clinical Oncology, vol. 17, no. 3, pp. 832–845, 1999. View at Google Scholar
  12. P. S. Gaynon, L. J. Ettinger, E. S. Baum, S. E. Siegel, M. D. Krailo, and G. D. Hammond, “Carboplatin in childhood brain tumors. A Children's Cancer Study Group Phase II trial,” Cancer, vol. 66, no. 12, pp. 2465–2469, 1990. View at Publisher · View at Google Scholar
  13. M. L. Slongo, B. Molena, A. M. Brunati et al., “Functional VEGF and VEGF receptors are expressed in human medulloblastomas,” Neuro-Oncology, vol. 9, no. 4, pp. 384–392, 2007. View at Publisher · View at Google Scholar · View at PubMed
  14. I. Sardi, D. Cavalieri, and M. Massimino, “Emerging treatments and gene expression profiling in high-risk medulloblastoma,” Pediatric Drugs, vol. 9, no. 2, pp. 81–96, 2007. View at Publisher · View at Google Scholar
  15. F. Grizzi, C. Weber, and A. Di Ieva, “Antiangiogenic strategies in medulloblastoma: reality or mystery,” Pediatric Research, vol. 63, no. 5, pp. 584–590, 2008. View at Publisher · View at Google Scholar · View at PubMed