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Journal of Oncology
Volume 2009, Article ID 305420, 6 pages
http://dx.doi.org/10.1155/2009/305420
Review Article

MicroRNAs as New Players for Diagnosis, Prognosis, and Therapeutic Targets in Breast Cancer

1Department of Surgery, The University of Hong Kong, Hong Kong
2Department of Molecular Pathology, Hong Kong Sanatorium & Hospital, Hong Kong

Received 1 February 2009; Revised 7 May 2009; Accepted 3 June 2009

Academic Editor: Katherine Crew

Copyright © 2009 Enders K. O. Ng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs are small nonprotein-coding RNAs that regulate the expressions of a wide variety of genes by sequence-specific base pairing on the 3 UTR of mRNA targets resulting in mRNA degradation or inhibition of translation. Aberrant expressions of miRNAs have been linked to tumor development, metastasis, diagnosis, prognosis, and therapy response in human breast cancer. Some miRNAs have been considered to have potential clinical applications as a tool for breast cancer prognosis and therapy. Here we describe and discuss lines of evidence supporting the important relationship between miRNAs and breast cancer, and its therapeutic strategies.