Analysis of Candidate Genes in Occurrence and Growth of Colorectal Adenomas
Table 3
Association analysis between single polymorphisms and colorectal adenomas.
Polymorphism
SA versus PF
LA versus PF
SA versus LA
TGFBR2.1
AC
0.91 [0.67−1.24]
1.06 [0.78−1.46]
1.22 [0.85−1.75]
CC
0.91 [0.58−1.41]
1.31 [0.85−2.02]
1.51 [0.91−2.51]
TGFBR2.2
GC
1.07 [0.79−1.44]
0.95 [0.69−1.28]
0.91 [0.64−1.29]
CC
1.23 [0.78−1.93]
1.18 [0.75−1.86]
0.91 [0.55−1.53]
TGFBR2.3
GC
0.93 [0.66−1.30]
1.00 [0.70−1.41]
1.08 [0.72−1.61]
CC
0.94 [0.63−1.41]
1.06 [0.70−1.59]
1.09 [0.68−1.74]
MLH1.1
AG
1.08 [0.79−1.46]
1.01 [0.74−1.38]
0.90 [0.63−1.29]
AA
1.11 [0.56−2.20]
1.80 [0.98−3.31]
1.64 [0.79−3.37]
MLH1.2
CT
1.04 [0.74−1.47]
1.14 [0.81−1.61]
1.08 [0.73−1.62]
C
1.18 [0.79−1.78]
1.08 [0.71−1.64]
0.90 [0.55−1.46]
MSH2.1
AG
0.97 [0.72−1.31]
0.93 [0.69−1.27]
0.94 [0.66−1.34]
GG
0.69 [0.43−1.13]
1.03 [0.65−1.62]
1.46 [0.83−2.54]
MSH2.2
AG
1.16 [0.86−1.57]
1.06 [0.78−1.44]
0.86 [0.60−1.23]
GG
0.98 [0.61−1.57]
1.02 [0.64−1.62]
1.10 [0.64−1.89]
MSH2.3
GT
0.88 [0.65−1.90]
0.99 [0.73−1.35]
1.11 [0.78−1.58]
GG
0.83 [0.45−1.53]
1.15 [0.65−2.04]
1.44 [0.72−2.85]
MSH2.4
CT
0.88 [0.65−1.20]
1.00 [0.74−1.37]
1.11 [0.77−1.58]
CC
1.00 [0.53−1.90]
0.82 [0.40−1.65]
0.88 [0.40−1.94]
MYH
GC
1.05 [0.78−1.41]
0.89 [0.66-1.21]
0.85 [0.59−1.21]
CC
0.86 [0.46−1.59]
1.06 [0.59-1.89]
1.15 [0.57−2.33]
P53.1
AG
0.95 [0.65−1.38]
1.37 [0.96−1.95]
1.43 [0.95−2.18]
GG
0.50 [0.14−1.81]
1.01 [0.36−2.82]
1.62 [0.39−6.78]
P53.2
GC
1.17 [0.87-1.58]
1.34 [0.99−1-81]
1.11 [0.78-1.57]
CC
1.35 [0.78−2.36]
1.25 [0.69−2.25]
0.91 [0.48−1.75]
P53.3
GC
1.25 [0.87−1.78]
1.13 [0.78−1.63]
0.91 [0.60−1.37]
CC
0.40 [0.11−1.41]
0.53 [0.17−1.62]
1.28 [0.27−6.09]
AXIN2.1
AT
1.23 [0.89−1.69]
1.13 [0.82−1.56]
0.90 [0.62−1.31]
AA
1.51 [1.01−2.27]
1.18 [0.78−1.79]
0.84 [0.53−1.35]
AXIN2.2
TC
1.06 [0.78−1.42]
0.95 [0.71−1.29]
0.93 [0.66−1.31]
TT
1.23 [0.67−2.25]
0.72 [0.36−1.43]
0.64 [0.30−1.35]
AXIN2.3
AG
1.20 [0.84−1.71]
1.21 [0.84−1.73]
0.96 [0.64−1.44]
GG
2.26 [0.64−8.01]
1.71 [0.45−6.52]
0.68 [0.18−2.66]
AXIN2.4
AT
1.22 [0.90−1.65]
1.40 [1.03−1.89]
1.13 [0.79−1.59]
TT
1.51 [0.89−2.58]
1.35 [0.77−2.36]
0.95 [0.52−1.76]
AG
1.26 [0.76−2.11]
0.86 [0.49−1.52]
0.70 [0.38−1.31]
AXIN2.6
AG
1.08 [0.79−1.46]
0.84 [0.62−1.15]
0.81 [0.57−1.16]
AA
1.23 [0.63−2.38]
0.99 [0.49−1.99]
0.82 [0.38−1.79]
AXIN2.7
AG
1.18 [0.88−1.59]
0.76 [0.56−1.04]
0.66 [0.47−0.94]
AA
1.48 [0.87−2.52]
1.07 [0.62−1.86]
0.74 [0.41−1.36]
AXIN2.8
GT
0.87 [0.62−1.23]
0.77 [0.55−1.08]
0.83 [0.56−1.24]
GG
1.11 [0.74−1.66]
0.91 [0.61−1.37]
0.78 [0.49−1.24]
AXIN2.9
AG
1.15 [0.83−1.60]
1.34 [0.95−1.91]
1.22 [0.82−1.82]
AA
0.96 [0.64−1.44]
1.67 [1.11−2.49]
1.86 [1.16−3.00]
BAX.1
TC
1.02 [0.73−1.42]
0.87 [0.61−1.22]
0.88 [0.59−1.29]
TT
1.19 [0.38−3.72]
1.16 [0.37−3.65]
1.02 [0.28−3.74]
BAX.2
AG
0.97 [0.72−1.30]
0.83 [0.61−1.12]
0.87 [0.61−1.23]
AA
1.05 [0.61−1.81]
1.23 [0.73−2.07]
1.24 [0.68−2.26]
TC
0.89 [0.55−1.45]
0.73 [0.43−1.23]
0.83 [0.46−1.52]
CTNNB1.1
AG
1.14 [0.83−1.56]
1.03 [0.75−1.42]
0.90 [0.62−1.31]
AA
1.23 [0.82−1.84]
1.21 [0.80−1.81]
0.93 [0.58−1.48]
CTNNB1.2
AG
1.12 [0.61−2.06]
1.41 [0.71−2.79]
1.22 [0.56−2.66]
AA
1.13 [0.62−2.04]
1.73 [0.89−3.37]
1.44 [0.67−3.07]
UGT1A1
(TA)6/(TA)7
1.18 [0.86−1.62]
1.04 [0.76−1.41]
0.88 [0.62−1.26]
(TA)7/(TA)7
0.63 [0.38−1.05]
0.70 [0.43−1.14]
1.00 [0.56−1.81]
GluGln
2.14 [0.67−7.00]
0.27 [0.01−2.11]
7.95 [1.05−354.36]
APC.2
AspVal
0.95 [0.70−1.28]
0.78 [0.57−1.05]
0.79 [0.56−1.14]
ValVal
1.20 [0.58−2.49]
0.94 [0.43−2.06]
0.73 [0.31−1.72]
GlyArg
1.01 [0.49−2.09]
0.51 [0.20−1.29]
0.50 [0.18−1.38]
Ins C
0.78 [0.39−1.56]
0.68 [0.33−1.39]
0.89 [0.38−2.09]
MDR1.1
GT
0.89 [0.63−1.25]
0.88 [0.63−1.22]
0.92 [0.63−1.36]
TT
1.32 [0.84−2.05]
1.15 [0.74−1.77]
0.91 [0.56−1.48]
AG
0.60 [0.22−1.64]
0.29 [0.08−1.03]
0.46 [0.11−1.99]
TA
2.86 [0.89−9.08]
1.27 [0.33−4.89]
0.41 [0.11−1.46]
MDR1.2
CT
1.00 [0.69−1.44]
0.76 [0.53−1.08]
0.69 [0.46−1.03]
TT
1.16 [0.76−1.79]
1.16 [0.78−1.74]
1.01 [0.63−1.61]
TS.1
2R/1R
0.99 [0.73−1.36]
1.25 [0.92−1.71]
1.24 [0.87−1.77]
1R/1R
1.35 [0.82−2.22]
1.33 [0.79−2.22]
0.99 [0.64−1.63]
TS.2
2R/3R
1.09 [0.75−1.59]
1.24 [0.85−1.82]
1.12 [0.72−1.75]
3R/3R
1.31 [0.86−1.98]
1.43 [0.94−2.16]
1.10 [0.68−1.78]
HRAS1
rare alleles
1.16 [0.83−1.61]
1.26 [0.91−1.75]
1.09 [0.75−1.59]
The genotype not shown is the reference one. OR adjusted on age, sex, and group of centres; 95% CI is given into brackets. Very few individuals with the homozygous genotype were observed.
