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Journal of Oncology
Volume 2009, Article ID 346345, 11 pages
http://dx.doi.org/10.1155/2009/346345
Review Article

Immunotherapy of Head and Neck Cancer: Current and Future Considerations

1Department of Head and Neck Surgery, Greek Anticancer Institute, Saint Savvas Hospital, 171 Alexandras Avenue, 115 22 Athens, Greece
2Department of Otolaryngology Head and Neck Surgery, A. Alfred Taubman Health Care Center, University of Michigan Health System, Ann Arbor, MI 48109, USA

Received 17 February 2009; Accepted 15 June 2009

Academic Editor: Amanda Psyrri

Copyright © 2009 Alexander D. Rapidis and Gregory T. Wolf. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [34 citations]

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  • K. Fritzsche, K. Breitenstein, and D. Esser, “Patients with malignancies of the oro- and hypopharynx as well as the larynx,” Hno, vol. 58, no. 8, pp. 756–761, 2010. View at PublisherView at Google Scholar
  • Kenneth Wilfried Kross, John-Helge Heimdal, and Hans Jorgen Aarstad, “Mononuclear phagocytes in head and neck squamous cell carcinoma,” European Archives of Oto-Rhino-Laryngology, vol. 267, no. 3, pp. 335–344, 2010. View at PublisherView at Google Scholar
  • Tibor Goeroegh, and Ulf Henning Beier, “Gene alterations in head and neck carcinomas and their role in promoting malignant behavior (Review),” International Journal Of Oncology, vol. 36, no. 3, pp. 525–532, 2010. View at PublisherView at Google Scholar
  • Tibor Görögh, and Ulf Henning Beier, “Gene alterations in head and neck carcinomas and their role in promoting malignant behavior (review),” International Journal of Oncology, vol. 36, no. 3, pp. 525–532, 2010. View at PublisherView at Google Scholar
  • Derrick Wansom, Emily Light, Frank Worden, Mark Prince, Susan Urba, Douglas B. Chepeha, Kitrina Cordell, Avraham Eisbruch, Jeremy Taylor, Nisha D'Silva, Jeffrey Moyer, Carol R. Bradford, David Kurnit, Bhavna Kumar, Thomas E. Carey, and Gregory T. Wolf, “Correlation of cellular immunity with human papillomavirus 16 status and outcome in patients with advanced oropharyngeal cancer,” Archives of Otolaryngology - Head and Neck Surgery, vol. 136, no. 12, pp. 1267–1273, 2010. View at PublisherView at Google Scholar
  • Mehrotra, Ibrahim, Eckardt, Driemel, and Singh, “Novel strategies in therapy of head and neck cancer,” Current Cancer Drug Targets, vol. 11, no. 4, pp. 465–478, 2011. View at PublisherView at Google Scholar
  • Gregory T. Wolf, Willard E. Fee, Robert W. Dolan, Jeffrey S. Moyer, Michael J. Kaplan, Paul M. Spring, James Suen, Daniel E. Kenady, Jason G. Newman, William R. Carroll, M. Boyd Gillespie, Scott M. Freeman, Lorraine Baltzer, Terry D. Kirkley, Harvey J. Brandwein, and John W. Hadden, “Novel Neoadjuvant Immunotherapy Regimen Safety And Survival In Head And Neck Squamous Cell Cancer,” Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck, vol. 33, no. 12, pp. 1666–1674, 2011. View at PublisherView at Google Scholar
  • M. Heusinkveld, R. Goedemans, R.J.P. Briet, H. Gelderblom, J.W.R. Nortier, A. Gorter, V.T.H.B.M. Smit, A.P.M. Langeveld, J.C. Jansen, and S.H. van der Burg, “Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer,” International Journal of Cancer, vol. 131, no. 2, pp. E74–E85, 2011. View at PublisherView at Google Scholar
  • Shahzad Raza, Noah Kornblum, Venkat P. Kancharla, Mahadi A. Baig, Amrit B. Singh, and Madhumati Kalavar, “Emerging therapies in the treatment of locally advanced squamous cell cancers of head and neck,” Recent Patents on Anti-Cancer Drug Discovery, vol. 6, no. 2, pp. 246–257, 2011. View at PublisherView at Google Scholar
  • Jutta Ries, Abbas Agaimy, Elefterios Vairaktars, Yeeun Kwon, Friedrich W. Neukam, Lei H. Strassburg, and Emeka Nkenke, “Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia,” International Journal Of Oncology, vol. 41, no. 3, pp. 1085–1093, 2012. View at PublisherView at Google Scholar
  • Jutta Ries, Abbas Agaimy, Elefterios Vairaktaris, Patricia Gorecki, Friedrich W. Neukam, Lei H. Straßburg, and Emeka Nkenke, “Detection of MAGE-A Expression Predicts Malignant Transformation of Oral Leukoplakia,” Cancer Investigation, vol. 30, no. 7, pp. 495–502, 2012. View at PublisherView at Google Scholar
  • Claudia Maria Pereira, Carolina Cavalieri Gomes, Jeane De Fatima Correia Silva, Monica Bucciarelli Rodriguez, Alvimar Afonso Barbosa, and Ricardo Santiago Gomez, “Evaluation of MAGE A1 in oral squamous cell carcinoma,” Oncology Reports, vol. 27, no. 6, pp. 1843–1848, 2012. View at PublisherView at Google Scholar
  • J. Lu, G. Li, W. -D. Tian, L. -H. Zhou, Q. Li, X. Liu, Z. Li, M. -L. He, B. Zhang, L. Wang, Y. Peng, and X. -P. Li, “Antitumor Effects of Interferon-Alpha on Cell Growth and Metastasis in Human Nasopharyngeal Carcinoma,” Current Cancer Drug Targets, vol. 12, no. 5, pp. 561–570, 2012. View at PublisherView at Google Scholar
  • Christopher Schutt, Klaus Bumm, Leonardo Mirandola, Giovanni Bernardini, Nicholas D' Cunha, Lukman Tijani, D Diane Nguyen, Joehassin Cordero, Marjorie R. Jenkins, Everardo Cobos, W. Martin Kast, and Maurizio Chiriva-Internati, “Immunological Treatment Options for Locoregionally Advanced Head and Neck Squamous Cell Carcinoma,” International Reviews Of Immunology, vol. 31, no. 1, pp. 22–42, 2012. View at PublisherView at Google Scholar
  • Clint T. Allen, Nancy P. Judd, Jack D. Bui, and Ravindra Uppaluri, “The clinical implications of antitumor immunity in head and neck cancer,” Laryngoscope, vol. 122, no. 1, pp. 144–157, 2012. View at PublisherView at Google Scholar
  • Krishnendu Chakraborty, Anamika Bose, Kuntal K. Goswami, Kalyan K. Mukherjee, Shyamal Goswami, Diptendu Ghosh, Tathagata Chakraborty, Koustav Sarkar, Smarajit Pal, Anup Bhowmick, Jaydip Biswas, and Rathindranath Baral, “Dysregulated CC receptor/ligand in monocytes/macrophages from tongue squamous cell carcinoma patients is partially rectified by interferon α-2b,” Human Immunology, vol. 73, no. 1, pp. 38–47, 2012. View at PublisherView at Google Scholar
  • Anil K. Chaturvedi, “Epidemiology and Clinical Aspects of HPV in Head and Neck Cancers,” Head and Neck Pathology, vol. 6, no. 1, pp. 16–24, 2012. View at PublisherView at Google Scholar
  • Zhao Yang, Tianzhi Zhao, and Yong Liu, “Upregulation of tumor suppressor WWOX promotes immune response in glioma,” Cellular Immunology, 2013. View at PublisherView at Google Scholar
  • Anne Skou Andersen, Anne Sophie Koldjaer Sølling, Therese Ovesen, and Maria Rusan, “The interplay between HPV and host immunity in head and neck squamous cell carcinoma,” International Journal of Cancer, 2013. View at PublisherView at Google Scholar
  • Vincent Varilla, Jonessa Atienza, and Constantin A Dasanu, “Immune alterations and immunotherapy prospects in head and neck cancer,” Expert Opinion on Biological Therapy, pp. 1–16, 2013. View at PublisherView at Google Scholar
  • Bastian Schilling, Malgorzata Harasymczuk, Patrick Schuler, James Egan, Soldano Ferrone, and Theresa L. Whiteside, “IRX-2, a Novel Immunotherapeutic, Enhances Functions of Human Dendritic Cells,” Plos One, vol. 8, no. 2, 2013. View at PublisherView at Google Scholar
  • Monika E. Freiser, Paolo Serafini, and Donald T. Weed, “The immune system and head and neck squamous cell carcinoma: from carcinogenesis to new therapeutic opportunities,” Immunologic Research, 2013. View at PublisherView at Google Scholar
  • Saly Al-Taei, Russell Banner, Ned Powell, Mererid Evans, Nachi Palaniappan, Zsuzsanna Tabi, and Stephen Man, “Decreased HPV-specific T cell responses and accumulation of immunosuppressive influences in oropharyngeal cancer patients following radical therapy,” Cancer Immunology, Immunotherapy, 2013. View at PublisherView at Google Scholar
  • Kristof Zarschler, Stefanie Witecy, Franz Kapplusch, Christian Foerster, and Holger Stephan, “High-yield production of functional soluble single-domain antibodies in the cytoplasm of Escherichia coli,” Microbial Cell Factories, vol. 12, 2013. View at PublisherView at Google Scholar
  • Annelies W Turksma, Boudewijn JM Braakhuis, Elisabeth Bloemena, Chris JLM Meijer, C René Leemans, and Erik Hooijberg, “Immunotherapy for head and neck cancer patients: shifting the balance,” Immunotherapy, vol. 5, no. 1, pp. 49–61, 2013. View at PublisherView at Google Scholar
  • Silvana Papagerakis, Giuseppe Pannone, Li Zheng, Imad About, Nawar Taqi, Nghia P.T. Nguyen, Margarite Matossian, Blake McAlpin, Angela Santoro, Jonathan McHugh, Mark E. Prince, and Petros Papagerakis, “Oral epithelial stem cells – implications in normal development and Cancer metastasis,” Experimental Cell Research, 2014. View at PublisherView at Google Scholar
  • Bengt-Åke Andersson, Freddi Lewin, Jan Lundgren, Mats Nilsson, Lars-Erik Rutqvist, Sture Löfgren, and Nongnit Laytragoon-Lewin, “Plasma tumor necrosis factor-α and C-reactive protein as biomarker for survival in head and neck squamous cell carcinoma,” Journal of Cancer Research and Clinical Oncology, 2014. View at PublisherView at Google Scholar
  • Paolo Serafini, and Donald T. Weed, “The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities,” Current Cancer Research, vol. 12, pp. 275–321, 2014. View at PublisherView at Google Scholar
  • J. Ochieng, G. N. Nangami, O. Ogunkua, I. R. Miousse, I. Koturbash, V. Odero-Marah, L. McCawley, P. Nangia-Makker, N. Ahmed, Y. Luqmani, Z. Chen, S. Papagerakis, G. T. Wolf, C. Dong, B. P. Zhou, D. G. Brown, A. Colacci, R. A. Hamid, C. Mondello, J. Raju, E. P. Ryan, J. Woodrick, I. Scovassi, N. Singh, M. Vaccari, R. Roy, S. Forte, L. Memeo, H. K. Salem, A. Amedei, R. Al-Temaimi, F. Al-Mulla, W. H. Bisson, and S. E. Eltom, “The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis,” Carcinogenesis, vol. 36, no. Suppl1, pp. S128–S159, 2015. View at PublisherView at Google Scholar
  • Belinda Hauser, Yuan Zhao, Xiaowu Pang, Zhiqiang Ling, Ernest Myers, Paul Wang, Joseph Califano, and Xinbin Gu, “Functions of MiRNA-128 on the Regulation of Head and Neck Squamous Cell Carcinoma Growth and Apoptosis,” Plos One, vol. 10, no. 3, 2015. View at PublisherView at Google Scholar
  • Asif A. Dar, Trupti N. Pradhan, Dakshayni P. Kulkarni, Sagar U. Shah, Kanury V. Rao, Devendra A. Chaukar, Anil K. D'Cruz, and Shubhada V. Chiplunkar, “ Extracellular 2′5′-oligoadenylate synthetase 2 mediates T-cell receptor CD3- ζ chain down-regulation via caspase-3 activation in oral cancer ,” Immunology, vol. 147, no. 2, pp. 251–264, 2015. View at PublisherView at Google Scholar
  • Nathan Handley, Jacob Eide, Randall Taylor, Beverly Wuertz, Patrick Gaffney, and Frank Ondrey, “PPARγ targeted oral cancer treatment and additional utility of genomics analytic techniques,” The Laryngoscope, 2016. View at PublisherView at Google Scholar
  • Yarden Shtenberg, Mor Goldfeder, Hodaya Prinz, Janna Shainsky, Yasmine Ghantous, Imad Abu El-Naaj, Avi Schroeder, and Havazelet Bianco-Peled, “Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery,” International Journal of Biological Macromolecules, 2017. View at PublisherView at Google Scholar
  • Aleyo Chabeda, Romana J.R. Yanez, Renate Lamprecht, Ann E. Meyers, Edward P. Rybicki, and Inga I. Hitzeroth, “Therapeutic vaccines for high-risk HPV-associated diseases,” Papillomavirus Research, 2017. View at PublisherView at Google Scholar