Journal of Oncology

Review Article

Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell Carcinomas

Table 1

Current classification of the NR superfamily into subfamilies according to sequence homology. Trivial abbreviations are given in brackets. NRs implicated in head and neck tumorigenesis are given in bold; asterisks indicate orphan receptors.


Subfamily	Full name	Subfamily members (trivial abbreviation)

Subfamily 1	Thyroid hormone receptor-like receptors

Subgroups	Peroxisome proliferator-activated receptors	Peroxisome proliferator-activated receptor (PPAR)
	Retinoic acid receptors	Retinoic acid receptor (RAR)
	Retinoic acid receptor-related orphan receptors	Retinoic acid receptor-related orphan receptor (ROR)
	Rev-ErbA	Rev-ErbA (EAR1)
	Thyroid hormone receptors	Thyroid hormone receptor (TR)
	Liver X receptor-like receptors	Liver X receptor (LXR) ; Farnesoid X receptor (FXR)
	Vitamin D receptor-like receptors	Vitamin D receptor (VDR); Pregnane X receptor (PXR); Constitutive androstane receptor (CAR)

Subfamily 2	Retinoid X receptor-like receptors

Subgroups	Hepatocyte nuclear factor-4	Hepatocyte nuclear factor-4 (HNF-4)
	Retinoid X receptors	Retinoid X receptor (RXR)
	Testicular receptors	Testicular receptor 2, 4 (TR2/4)
	Tailless-like receptors	Human homologue of the Drosophila tailless gene (TLX); Photoreceptor cell-specific nuclear receptor (PNR)
	Chicken ovalbumin upstream promoter-transcription factor-like receptors	Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) I, II; V-erbA-related (EAR2)

Subfamily 3	Estrogen receptor-like receptors

Subgroups	Estrogen receptors	Estrogen receptor (ER)
	Estrogen related receptors	Estrogen-related receptor (ERR)
	3-Ketosteroid receptors	Androgen receptor (AR); Progesterone receptor (PR);Glucocorticoid receptor (GR); Mineralocorticoid receptor (MR);

Subfamily 4	Nerve growth factor IB-like receptors

	Nerve Growth factor IB/ Nuclear receptor related/ Neuron-derived orphan receptor	Nerve Growth factor IB (NGF-IB); Nuclear receptor related 1 (NURR1); Neuron-derived orphan receptor 1 (NOR1)

Subfamily 5	Steroidogenic factor-like receptors

	Steroidogenic factor/Liver receptor homolog	Steroidogenic factor 1 (SF1); Liver receptor homologue-1 (LHR1)

Subfamily 6	Germ cell nuclear factor-like receptors

	Germ cell nuclear factor	Germ cell nuclear factor (GCNF)

Subfamily 0	Miscellaneous receptors

	Dosage-sensitive sex reversal, adrenal hypoplasia critical region/Small heterodimer partner	Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX); Small heterodimer partner (SHP)