Journal of Oncology / 2009 / Article / Fig 1

Research Article

Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals

Figure 1

Dose-response curves for CXCR4 and CXCL12 mRNAs after treatment of breast and ovarian cancer cells with 1–10  M genistein. (a) CXCR4 and CXCL12 mRNA quantification after treatment of MCF-7 cells with increasing concentrations of genistein for 24 hours. (b) CXCR4 quantification after treatment of MDA-MB-231 cells with genistein for 24 hours. MDA-MB-231 cells do not express CXCL12 as determined by real-time PCR. (c) CXCR4 and CXCL12 quantification after treatment of BG-1 cells with increasing doses of genistein for 24 hours. All data were normalized to corresponding mRNA quantities for the 36B4 housekeeping gene. , , ; relative to 0 M genistein control.
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(a) MCF-7
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(b) MDA-MB-231
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(c) BG-1

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