Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals
Figure 1
Dose-response curves for CXCR4 and
CXCL12 mRNAs after treatment of breast and ovarian cancer cells with 1–10 M genistein. (a) CXCR4 and CXCL12 mRNA quantification after treatment of MCF-7 cells with
increasing concentrations of genistein for 24 hours. (b) CXCR4 quantification after
treatment of MDA-MB-231 cells with genistein for 24 hours. MDA-MB-231 cells do
not express CXCL12 as determined by real-time PCR. (c) CXCR4 and CXCL12
quantification after treatment of BG-1 cells with increasing doses of genistein
for 24 hours. All data were normalized to corresponding mRNA quantities for the
36B4 housekeeping gene. , , ; relative to 0 M genistein
control.
