Journal of Oncology / 2009 / Article / Fig 2

Research Article

Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals

Figure 2

Genistein downregulates CXCR4 surface expression and intracellular CXCL12 expression. Downregulation of CXCR4 protein expression in MCF-7, MDA-MB-231, and BG-1 cells at concentrations of genistein ranging from 0–100  M for a 24-hour period (a)–(c). Downregulation of intracellular CXCL12 protein expression in (a) MCF-7 and (c) BG-1 cells at 30–100  M genistein. Fluorescence distribution plots depict one representative experiment. Isotype controls are represented by filled histograms. Mean fluorescence intensities (MFI) and their corresponding standard deviations are derived from three independent experiments.
(a) MCF-7
(b) MDA-MB-231
(c) BG-1

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