Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells
Figure 2
Effect of perifosine (PER) in head and neck cancer cell growth and survival. FaDu (a), Cal-27 (b), and SCC-25 (c) cells were treated with 1, 5, and 10 mol/L PER and grown for 72 hours. (d) Cells were treated with 1–10 M PER for 24 hours then plated for clonogenic survival. Clonogenic cell survival data were normalized to control (CON). Error bars represent ± 1SD of experiments performed on different days with at least 2 cloning dishes taken from 1 treatment dish. *, versus control.
