Anti-EGFR-Targeted Therapy for Esophageal and Gastric Cancers: An Evolving Concept

Table 1

Trials of oral EGFR tyrosine kinase inhibitors.

	Phase	Number of patients	Anatomic site	Histology	Treatment regimen	Outcomes	Comments
Ferry et al. [8]	II	27	Esophagus	27/27 adenocarcinoma	Gefitinib 500 mg PO daily	mOS 4.5 months mPFS 1.9 months 3/27 PR (11%) 7/27 SD (26%)	Prior chemotherapy: 18/27 (67%)
Janmaat et al. [9]	II	36	Esophagus	26/36 adenocarcinoma (72%) 9/36 squamous cell (25%) 1/36 adenosquamous (3%)	Gefitinib 500 mg PO daily	mOS 5.5 months mPFS 2 months 1/36 PR (3%) 10/36 SD (28%)	Second-line treatment 8/36 not assessable for response
Dragovich et al. [10]	II	70	26/70 Gastric (37%) 44/70 GEJ (63%)	70/70 adenocarcinoma	Erlotinib 150 mg PO daily	mOS GEJ 6.7 months mOS Gastric 3.5 months mTTF GEJ 2 months mTTF Gastric 1.6 months GEJ: 1/43 CR (2%), 3/43 PR (7%), 5/43 SD (12%)	All responses in esophageal GEJ cohort No responses seen in the gastric cohort
Hecht et al. [11]	II	25	13/25 GEJ (52%) 12/25 Esophagus (48%)	25/25 adenocarcinoma	Lapatinib 1000–1500 mg PO daily	No responses seen 2/25 SD (8%)	Elevated TGF-alpha expression correlated with shorter TTP