Journal of Oncology

Research Article

Transcriptional Activity of Human Epidermal Growth Factor Receptor Family and Angiogenesis Effectors in Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma and Correlation with Patient Outcome

Table 3

Association of mRNA expression the HER family genes with clinicopathological parameters.
EGFR HER2 HER3 HER4
LowHigh LowHigh LowHigh LowHigh
Alcohol Consumption.577.404.259.239
 Low5 (24)8 (40)8 (44)5 (28)9 (43)4 (20)9 (45)4 (21)
 Moderate9 (43)7 (35)7 (39)6 (33)6 (29)10 (50)6 (30)10 (53)
 High7 (33)5 (25)3 (17)7 (39)6 (29)6 (30)5 (25)5 (26)
Site of relapse.999.501.812.545
 Local only14 (67)13 (65)13 (72)13 (72)13 (62)14 (70)12 (60)15 (79)
 Lymph nodes ± Local3 (14)3 (15)2 (11)4 (22)4 (19)2 (10)3 (15)2 (11)
 Other4 (19)4 (20)3 (17)1 (6)4 (19)4 (20)5 (25)2 (11)
Size at 1st relapse.425.256.145.716
   cm4 (19)3 (15)3 (17)4 (22)4 (19)3 (15)3 (15)4 (21)
 2–4 cm9 (43)13 (65)8 (44)10 (56)9 (43)13 (66)11 (55)10 (53)
   cm5 (24)2 (10)5 (28)1 (6)6 (29)1 (5)5 (25)2 (10)
 Unknown3 (14)2 (10)2 (11)3 (17)2 (10)3 (15)1 (5)3 (16)
Lymph nodes at diagnosis.999.999.999.999
 N018 (86)18 (90)16 (89)16 (89)18 (86)18 (90)17 (85)17 (89)
 N1-N22 (10)2 (10)2 (11)2 (11)2 (10)2 (10)2 (10)2 (11)
 Unknown1 (5)0 (0)0 (0)(0)1 (5)0 (0)1 (5)0 (0)
Differentiation grade at relapse.240.417.999.448
 Well or moderate13 (62)12 (60)13 (72)9 (50)12 (57)13 (65)12 (60)13 (81)
 Poor or undifferentiated2 (10)7 (35)3 (17)5 (28)4 (19)5 (25)6 (33)3 (19)
 Unknown6 (29)1 (5)2 (11)4 (22)5 (24)2 (10)2 (10)3 (16)
Pack years exposure.999.999.999.205
  11 (52)11 (55)10 (56)9 (50)11 (52)11 (55)8 (40)12 (63)
  10 (48)9 (45)8 (44)9 (50)10 (48)9 (45)12 (60)7 (37)
Age.217.094.538.752
  13 (62)8 (40)12 (67)6 (33)12 (57)9 (45)11 (55)9 (47)
  8 (38)12 (60)6 (33)12 (67)9 (43)11 (55)9 (45)10 (53)
Diagnosis to recurrence Interval.530.305.341.748
  months7 (33)9 (45)9 (50)5 (28)10 (48)6 (30)9 (45)7 (37)
  months14 (67)11 (55)9 (50)13 (72)11 (52)14 (70)11 (55)12 (63)