Precursor Lesions of High-Grade Serous Ovarian Carcinoma: Morphological and Molecular Characteristics
Figure 2
Serous tubal intraepithelial lesion (STIL). (a) The morphological features of an STIL identified in a young cancer-free BRCA mutation carrier. The epithelium shows mild nuclear and architectural atypia but not to the level of a classical STIC. (b) An immunohistochemical stain for p53 shows overexpression in several consecutive secretory cells. (c) An immunohistochemical stain for Ki-67 shows a low proliferation index.
