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Journal of Oncology
Volume 2010, Article ID 135632, 15 pages
http://dx.doi.org/10.1155/2010/135632
Review Article

MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma

1Institute of Pharmacology, National Yang-Ming University, Taipei 11221, Taiwan
2Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan
3Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
4Institute of Oral Biology and Biomaterial Science, Chung Shan Medical University, Taichung 40201, Taiwan
5Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei 11221, Taiwan
6Division of Oral and Maxillofacial Surgery, Department of Stomatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
7Institute of Anatomy and Cell Biology, National Yang-Ming University, Taipei 11221, Taiwan
8School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
9Otolaryngology & Head and Neck Surgery, Department of Otolaryngology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
10Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan
11Cancer Center, Taipei Veterans General Hospital, Taipei 11217, Taiwan

Received 18 October 2010; Accepted 30 December 2010

Academic Editor: Paul Magnus Schneider

Copyright © 2010 Li-Hsin Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs have emerged as important regulators of cell proliferation, development, cancer formation, stress responses, cell death, and other physiological conditions in the past decade. On the other hand, head and neck cancer is one of the top ten most common cancers worldwide. Recent advances in microRNAs have revealed their prominent role in regulating gene expression and provided new aspects of applications in diagnosis, prognosis, and therapeutic strategies in head and neck squamous carcinoma. In the present paper, we focus on microRNAs showing significant differences between normal and tumor cells or between cells with differential ability of metastasis. We also emphasize specific microRNAs that could modulate tumor cell properties, such as apoptosis, metastasis, and proliferation. These microRNAs possess the potential to be applied on clinical therapy in the future.