Expression of Chemoresistance-Related Genes and Heat Shock Protein 72 in Hyperthermic Isolated Limb Perfusion of Malignant Melanoma: An Experimental Study

Table 4

Group IV (𝑛=9). Gene expression by variation of perfusion time at hyperthermic conditions with vinblastine (gene expression/number of tumor samples), n.d. = not done (see text).

	Untreated tumor	Perfusion time (minutes)
		30	60	90	60 + 5 hours
Gene
mdr1	3/3	3/3	3/3	n.d.	3/3
mrp1	3/3	3/3	3/3	n.d.	3/3
mrp2	0/3	1/3	1/3	n.d.	0/3
lrp	3/3	3/3	3/3	n.d.	3/3