Angiogenesis: From Chronic Liver Inflammation to Hepatocellular Carcinoma

Figure 3

Innate immunity-driven angiogenesis: immune cells, mostly neutrophils and monocyte-macrophages, mediate initial tunnel formation in certain models of angiogenesis. Other myeloid cell types, such as dendritic cells (DCs) and natural killer cells (NK), produce angiogenic factors that attract endothelial cells that become essential components of developing blood vessels. Adapted from Noonan et al., 2008.