Disrupting Ovarian Cancer Metastatic Colonization: Insights from Metastasis Suppressor Studies
Figure 3
Summary of the effect of MKK7, JNKK1/MKK4, and MKK6 on SKOV3ip.1 metastasis formation. (a) Schematic of JNKK1/MKK4’s signaling cascade. In vivo studies show that in SKOV3ip.1 cells, activation of p38 by ectopic expression of JNKK1/MKK4 or MKK6 causes metastasis suppression. (b) Images depicting the effect of specific proteins on metastasis formation, (Complete primary data can be found in [12, 19]).
