Disrupting Ovarian Cancer Metastatic Colonization: Insights from Metastasis Suppressor Studies
Figure 4
SKOV3ip.1-JNKK1/MKK4 microscopic metastases show decreased proliferation. (a) TUNEL reaction for apoptotic cells was quantitated and showed only rare positive cells. (b) Immunolabeling for BrdU in SKOV3ip1-vector and SKOV3ip.1-HA-JNKK1 microscopic metastases (outlined in black) at 14 dpi (100 magnification). Both size and BrdU incorporation were significantly decreased in SKOV3ip.1-JNKK1/MKK4 metastases compared to SKOV3ip.1-vector metastases. (c) p21 nuclear staining was significantly decreased in SKOV3ip.1-JNKK1/MKK4 metastases compared to SKOV3ip.1-vector metastases, (Data adapted from [20]).