Review Article

Targeted Therapies in Epithelial Ovarian Cancer

Table 3

Major risks factors potentially associated with bevacizumab-induced arterial thrombo-embolism and gastrointestinal perforation.

1- Arterial Thromboembolic Events (ATEs) [26]
 –Age 65 years
 –Prior history of ATE
2- Gastrointestinal Perforation [27, 28]
 –Multiple prior chemotherapy regimens (heavily pretreated patients)
 –Large intraabdominal tumor burden
 –Neoplastic bowel involvement
 –Clinical evidence of partial obstruction