Low Level of Her-2 Locus Amplification by Fluorescent In Situ Hybridization Does Not Correlate with Her-2 Protein Overexpression by Immunohistochemistry in Barrett's Esophagus

Table 2

Frequencies of Her-2 protein overexpression in BE/EAC patients with respect to high and low levels of Her-2 locus amplification versus no amplification (Cep17 gain).

FISH	IHC		P*
	0/+1	+2/+3
	No./total No. (%)
No amplification (Cep 17 gain)	19/22 (86)	3/22 (14)	.001
Her-2 high amplification	1/7 (14)	6/7 (86)
No amplification (Cep17 gain)	19/22 (86)	3/22 (14)	1
Her-2 low amplification	4/5 (80)	1/5 (20)

FISH—fluorescent in situ hybridization, IHC—immunohistochemistry, *Fisher exact test.