Locking Src/Abl Tyrosine Kinase Activities Regulate Cell Differentiation and Invasion of Human Cervical Cancer Cells Expressing E6/E7 Oncoproteins of High-Risk HPV
Figure 5
Comparison of SKI-606 and Iressa activity against cell migration and invasion ability of the HeLa cell line. SKI-606 and, to a lesser extent, Iressa block cell migration at the same concentrations, as indicated in Materials and Methods, (arrows) within 48 hours in comparison with untreated (control), () using a cell wounding assay. In parallel, SKI-606 dramatically inhibits cell invasion ability of HeLa and SiHa cells (data not shown) in comparison with Iressa-treated and untreated (control) cells (arrows indicate invasive cells), () using Boyden chambers. Experiments conducted on SiHa cells showed the same data regarding cell migration and invasion ability.
