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Journal of Oncology
Volume 2010, Article ID 576384, 7 pages
Review Article

Angiogenesis and Breast Cancer

1Laboratory of Medical Investigation (LIM) , School of Medicine, University of São Paulo, 01246-903 São Paulo-SP, Brazil
2School of Health Sciences, Life and Health Sciences Research Institute, University of Minho, Campos of Gualtar, 4710-057 Braga, Portugal
3Institute of Molecular Pathology and Immunology, University of Porto, IPATIMUP, Rua Roberto Frias s/n, 4200 Porto, Portugal
4Medical Faculty, Porto University, 4099-002 Porto, Portugal

Received 12 April 2010; Revised 29 July 2010; Accepted 2 September 2010

Academic Editor: Michael A. Carducci

Copyright © 2010 Adhemar Longatto Filho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Angiogenesis is an essential step for breast cancer progression and dissemination. The development of new blood vessels in cancer setting (angiogenesis) is conducted by numerous physiological and pathological stimuli, where the main stimulus is hypoxia. The knowledge of different molecular pathways regulating angiogenesis is constantly growing. An increased and complex scenario of angiogenesis is nowadays available in breast cancer, specifically, and permits not only to understand most of the important phases of neoplastic growth but also offer an exciting perspective for new therapeutic proposals based on blocking new blood vessels sprouting. This review focused on historical and recent understanding of angiogenesis occurrence in breast cancer.