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Journal of Oncology
Volume 2010, Article ID 586905, 13 pages
Review Article

Extracellular Matrix Proteins and Tumor Angiogenesis

1Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
2CIHR Group in Matrix Biology, University of Toronto, ON, Canada M5G 1G6
3Department of Pathobiology, University of Guelph, Guelph, ON, Canada N1G 2W1

Received 2 November 2009; Accepted 26 May 2010

Academic Editor: Kalpna Gupta

Copyright © 2010 N. E. Campbell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tumor development is a complex process that relies on interaction and communication between a number of cellular compartments. Much of the mass of a solid tumor is comprised of the stroma which is richly invested with extracellular matrix. Within this matrix are a host of matricellular proteins that regulate the expression and function of a myriad of proteins that regulate tumorigenic processes. One of the processes that is vital to tumor growth and progression is angiogenesis, or the formation of new blood vessels from preexisting vasculature. Within the extracellular matrix are structural proteins, a host of proteases, and resident pro- and antiangiogenic factors that control tumor angiogenesis in a tightly regulated fashion. This paper discusses the role that the extracellular matrix and ECM proteins play in the regulation of tumor angiogenesis.