Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin 𝛼6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion

Figure 1

TSP-1 upregulates integrin 𝛼6 subunit message in human keratinocytes. Keratinocytes were treated with either bis-tris-propane buffer or TSP-1 (60 𝜇g/mL) in serum-free media and mRNA expression was analyzed by (a) differential display analysis and confirmed with (b) northern blot analysis. Experiments were repeated three times and the results of a representative experiment are shown in the figure.