Role of Angiopoietin-2 in Regulating Growth and Vascularity of Astrocytomas
Figure 1
Effect of Ang2 over-expression on growth of GBM xenografts. Stable clones of U87 and U373 were generated to over-express Ang2 constitutively. Neither of the cell lines expresses Ang2 at baseline. One highest expressing clone and one pooled clone of each cell line was grown as subcutaneous models. Ang2 restricted tumor growth in U373 (a) tumors while it conferred a growth advantage in U87 tumors (b). Similarly, a growth advantage was maintained in U87 intracranial xenografts as evidenced by a significantly lowered survival time of mice with these grafts compared to mice with control tumors, and this increased tumor growth was dose dependent on Ang2 (c).
