Journal of Oncology / 2010 / Article / Fig 7

Research Article

Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68

Figure 7

Immunohistochemical staining of MTH52c tumors. Tumor-bearing mice were i.v. injected either with 5×106  pfu of At day 42 after injection, GLV-1h68 (A and AI) or PBS (B and BI). whole tumor cross-sections (100 μm) were labeled either with antivaccinia virus or Phalloidin-TRITC (I) antibodies (both red) and analyzed by fluorescence microscopy to detect GFP (green) and actin or vaccinia virus-dependent (red) fluorescence. Scale bars represent 5 mm. *Large areas lacking actin staining indicate dead tumor tissue damaged by GLV-1h68.

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