Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides
T-oligo treatment inhibits EC tubulogenesis in vitro. HMVEC cells were plated on Matrigel in four-well chamber slides and treated in triplicate with T-oligo or diluent alone, as described in the text. (a) All representative images are taken 22 hours after plating cells into chambers, the time of biggest differences among treatment conditions. (b) The length of tube-like structures was quantified as total average tube lengths per visual field from 3 separate chambers for each treatment condition. The differences in the length of tube-like structures were quantified (in pixels) in at least 3–5 representative photographs per chamber/treatment condition using computer-assisted image analysis.
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