Ganglioside GM3 Is Antiangiogenic in Malignant Brain Cancer

Figure 2

Pathway for the synthesis of ganglioside GM2 from GM3 by GalNAc-T. GalNAc-T adds a beta-linked N-acetylgalactosamine residue to the galactose of GM3 to form GM2, a key step required for the synthesis of complex gangliosides, GM2, GM1, and GD1a. Antisense targeting of the GalNAc-T gene reduces GD1a content, while increasing GM3 content [7].