Breast Carcinoma Cells in Primary Tumors and Effusions Have Different Gene Array Profiles
Figure 1
Breast carcinoma effusion and primary carcinoma expression arrays. (a): Volcano plot of differentially expressed genes in malignant effusions in comparison to pooled primary tumors (). The x-axis indicates the differential expression profiles, plotting the fold-induction ratios in a log-2 scale. The y-axis indicates the statistical significance of the difference in expression (P-value, t-test) in a -log10 scale. Differentially expressed genes () appear above the horizontal line. Numbers denote up-regulated (red) or down-regulated (blue) genes in effusions. (b): Gene expression profiling of effusions (blue) and primary breast carcinomas (red) in three-dimensional space by Principal Component Analysis using 351 genes that showed significant up- or downregulation in effusions in comparison to the pooled primary tumor sample (two different view angles). (c): Gene expression profiling of 11 effusions (blue) and 11 primary carcinomas (red) in three-dimensional space by Principal Component Analysis (three different view angles).
