Oxaliplatin-Induced Neuropathy in Colorectal Cancer

Table 1

Common terminology criteria for adverse events version 4.03.

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Dysesthesia	Mild sensory alteration	Moderate sensory alteration; limiting instrumental ADL	Severe sensory alteration; limiting self-care ADL	—	—
Paresthesia	Mild symptoms	Moderate symptoms; limiting instrumental ADL	Severe symptoms; limiting self care ADL	—	—
Peripheral sensory neuropathy	Asymptomatic; loss of deep tendon reflexes or paresthesia	Moderate symptoms; limiting instrumental ADL	Severe symptoms; limiting self care ADL	Life-threatening; consequences; urgent intervention indicated	Death
Peripheral motor neuropathy	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Moderate symptoms; limiting instrumental ADL	Severe symptoms; limiting self care ADL; assistive device indicated	Life-threatening; consequences; urgent intervention indicated	Death