Research Article
Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres
Table 4
Frequency of genetic and epigenetic alterations in primary tumors, NS and AC.
| | Molecular marker | Primary GBM (%) | NS (%) | AC* (%) |
| | LOH 1p, 9p, 10q, 17p, 19q | 16 (100) | 6 (100) | 0 (0) | | EGFR amplification | 8 (50) | 3 (45) | 0 (0) | | MGMT hypermethylation | 9 (50) | 4 (66.7) | 0 (0) | | TP53 mutations | 5 (31.2) | 3 (50) | 0 (0) | | PTEN mutations | 9 (56.2) | 4 (66.7) | 2 (22.2) | | EGFR mutations | 1 (<1) | 0 (0) | 0 (0) | | p.R132 IDH1 | 0 (0) | 0 (0) | 0 (0) | | p.R172 IDH2 | 0 (0) | 0 (0) | 0 (0) |
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*An exception is CV10 in which NS generated from AC. AC showed the same molecular profile of NS.
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