Mitochondrial DNA Content Varies with Pathological Characteristics of Breast Cancer

Table 2

Somatic alterations and alterations of mtDNA content.

Regions with somatic alterations

Alteration of mtDNA content

mtDNA content in tumor tissue

T/N ratio

T/N ratio < 0.8

T/N ratio > 1.2

Mean ± SD

P value*

Mean ± SD

P value*

n

%

Odds

95% CI (Low-High)

P value **

n

%

Odds

95% CI (low-High)

P value **

A

D-loop only (𝑛=19)

496 ± 181

<0.001 ^Δ

0.65 ± 0.35

<0.001 ^Δ

11

57.9

1.38

0.46–4.14

0.591^Δ

1

5.3

0.15

0.02–1.23

0.081

B

Coding with/ without D-loop (𝑛=15)

724 ± 369

<0.001 ^Δ; <0.001 ^ΔΔ

1.35 ± 0.71

<0.001 ^Δ; <0.001 ^ΔΔ

4

26.7

0.36; 0.26

0.1–1.34; 0.06–1.14

0.141 ^Δ; 0.091 ^ΔΔ

9

60

3.95; 27

1.14–13.73; 2.81–26

0.033 ^Δ; 0.001 ^ΔΔ

C

No (𝑛=40)

562 ± 310

1.22 ± 1.41

20

50

11

27.5

T/N ratio: the ratio of mtDNA content in tumor tissue to the mtDNA content in surrounding normal tissue; SD: standard deviation; *: Mann-Whitney test; **: Fisher’s exact test, ^Δversus no somatic alterations (C); ^ΔΔversus non-coding D-loop region alterations only (A). The P values <0.05 are in bold, indicating significance; the P values >0.05, but <0.15 are in italic, indicating weak significance.