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Journal of Oncology
Volume 2011, Article ID 518394, 6 pages
Research Article

Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer

1Department of Surgery and Jefferson Pancreatic, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
2Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA 1015, USA
3Department of Pathology Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 1015, USA

Received 25 March 2011; Revised 28 July 2011; Accepted 2 August 2011

Academic Editor: Judith A. Smith

Copyright © 2011 Jennifer Sullivan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background/Aims. Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients. Methods. ELISA was used to analyze MCP-1 serum levels in PDA ( ) and intraductal papillary mucinous neoplasms (IPMN) ( ). Recursive partitioning statistical analysis investigated the relationship between log MCP-1 and clinicopathological parameters. Results. Log MCP-1 values were significantly ( ) elevated in patients with BMI ≥ 37.5. In patients with BMI < 37.5, average log MCP-1 values were significantly elevated in PDA patients when compared to IPMN patients. Within the IPMN group, higher log MCP-1 levels correlated with increased age. Recursive partitioning analysis of IPMN versus PDA revealed a strategy of predicting characteristics of patients who are more likely to have cancer. This strategy utilizes log MCP-1 as the primary factor and also utilizes smoking status, gender, and age. Conclusion. MCP-1 is a promising biomarker in pancreatic cancer. The potential of using MCP-1 to distinguish PDA from IPMN patients must be studied in larger populations to validate and demonstrate its eventual clinical utility.