Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells
Figure 4
Determination of the role of Bmi-1 on in vivo tumor growth and radioresistance in HNSCC-ALDH1+ cells. (a) Tumor volume was measured after injection of either HNSCC-ALDH1+, sh-Bmi-1 treated HNSCC-ALDH1+, HNSCC-ALDH1-, or Bmi-1-overexpressing HNSCC- ALDH1- cells into the neck of SCID mice. Error bars correspond to SD. (b) To determine the radiation effect on the cell survival rate, an ionizing radiation (IR) dose from 0 to 10Gy was used to treated with ALDH1+/vector, ALDH1+/sh-Bmi-1, ALDH1- /vector, or Bmi-1-overexpressing HNSCC- ALDH1- HNSCC cells.
