Research Article

Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells

Table 3

The expression profiling of up-regulated genes in ALDH1-/Bmi1-overexpressed as compared to ALDH1- HNSCC.

Probe set IDGene symbolGene title

217757_atA2Malpha-2-macroglobulin
209459_s_atABAT4-aminobutyrate aminotransferase
213353_atABCA5ATP-binding cassette, sub-family A (ABC1), member 5
209993_atABCB1(MDR1)ATP-binding cassette, sub-family B (MDR/TAP), member 1
214033_atABCC6ATP-binding cassette, sub-family C (CFTR/MRP), member 6
210246_s_atABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8
204567_s_atABCG1ATP-binding cassette, sub-family G (WHITE), member 1
209735_atABCG2ATP-binding cassette, sub-family G (WHITE), member 2
204151_x_atAKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
209699_x_atAKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
212224_atALDH1A1aldehyde dehydrogenase 1 family, member A1
204446_s_atALOX5arachidonate 5-lipoxygenase
205216_s_atAPOHapolipoprotein H (beta-2-glycoprotein I)
39248_atAQP3aquaporin 3 (Gill blood group)
218501_atARHGEF3Rho guanine nucleotide exchange factor (GEF) 3
219087_atASPNAspirin
201242_s_atATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptide
200921_s_atBTG1B-cell translocation gene 1, anti-proliferative
228067_atC2orf55chromosome 2 open reading frame 55
206488_s_atCD36CD36 molecule (thrombospondin receptor)
208783_s_atCD46CD46 molecule, complement regulatory protein
1553970_s_atCELcarboxyl ester lipase (bile salt-stimulated lipase)
203854_atCFIcomplement factor I
205043_atCFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
204260_atCHGBchromogranin B (secretogranin 1)
221188_s_atCIDEBcell death-inducing DFFA-like effector b
203953_s_atCLDN3claudin 3
221042_s_atCLMNcalmin (calponin-like, transmembrane)
1567081_x_atCLN6ceroid-lipofuscinosis, neuronal 6, late infantile, variant
208791_atCLUClusterin
229831_atCNTN3contactin 3 (plasmacytoma associated)
205615_atCPA1carboxypeptidase A1 (pancreatic)
206212_atCPA2carboxypeptidase A2 (pancreatic)
205509_atCPB1carboxypeptidase B1 (tissue)
201117_s_atCPEcarboxypeptidase E
224829_atCPEB4cytoplasmic polyadenylation element binding protein 4
204920_atCPS1carbamoyl-phosphate synthetase 1, mitochondrial
201990_s_atCREBL2cAMP responsive element binding protein-like 2
205971_s_atCTRB1 /// CTRB2chymotrypsinogen B1 /// chymotrypsinogen B2
214411_x_atCTRB2chymotrypsinogen B2
209774_x_atCXCL2chemokine (C-X-C motif) ligand 2
205765_atCYP3A5cytochrome P450, family 3, subfamily A, polypeptide 5
228391_atCYP4V2cytochrome P450, family 4, subfamily V, polypeptide 2
228739_atCYS1cystin 1
222925_atDCDC2doublecortin domain containing 2
205311_atDDCdopa decarboxylase (aromatic L-amino acid decarboxylase)
210397_atDEFB1defensin, beta 1
221081_s_atDENND2DDENN/MADD domain containing 2D
214787_atDENND4ADENN/MADD domain containing 4A
205684_s_atDENND4CDENN/MADD domain containing 4C
214079_atDHRS2dehydrogenase/reductase (SDR family) member 2
222850_s_atDNAJB14DnaJ (Hsp40) homolog, subfamily B, member 14
225415_atDTX3Ldeltex 3-like (Drosophila)
225645_atEHFEts homologous factor
210080_x_atELA3Aelastase 3A, pancreatic
201510_atELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific)
206191_atENTPD3ectonucleoside triphosphate diphosphohydrolase 3
220012_atERO1LBERO1-like beta (S. cerevisiae)
210103_s_atFOXA2forkhead box A2
235201_atFOXP2forkhead box P2
226847_atFSTFollistatin
205674_x_atFXYD2FXYD domain containing ion transport regulator 2
205890_s_atGABBR1 /// UBDgamma-aminobutyric acid (GABA) B receptor, 1 /// ubiquitin D
205848_atGAS2growth arrest-specific 2
216733_s_atGATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)
204965_atGCgroup-specific component (vitamin D binding protein)
219508_atGCNT3glucosaminyl (N-acetyl) transferase 3, mucin type
225853_atGNPNAT1glucosamine-phosphate N-acetyltransferase 1
212950_atGPR116G protein-coupled receptor 116
212070_atGPR56G protein-coupled receptor 56
203924_atGSTA1glutathione S-transferase A1
221942_s_atGUCY1A3guanylate cyclase 1, soluble, alpha 3
228697_atHINT3histidine triad nucleotide binding protein 3
209558_s_atHIP1Rhuntingtin interacting protein 1 related
207062_atIAPPislet amyloid polypeptide
213620_s_atICAM2intercellular adhesion molecule 2
203828_s_atIL32interleukin 32
205945_atIL6Rinterleukin 6 receptor
206598_atINSInsulin
226535_atITGB6integrin, beta 6
226189_atITGB8integrin, beta 8
210078_s_atKCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 1
219564_atKCNJ16potassium inwardly-rectifying channel, subfamily J, member 16
205303_atKCNJ8potassium inwardly-rectifying channel, subfamily J, member 8
212531_atLCN2lipocalin 2
235970_atLCORLligand dependent nuclear receptor corepressor-like
1554006_a_atLLGL2lethal giant larvae homolog 2 (Drosophila)
225996_atLONRF2LON peptidase N-terminal domain and ring finger 2
242931_atLONRF3LON peptidase N-terminal domain and ring finger 3
226748_atLYSMD2LysM, putative peptidoglycan-binding, domain containing 2
213975_s_atLYZlysozyme (renal amyloidosis)
222670_s_atMAFBv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
223577_x_atMALAT1metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
220945_x_atMANSC1MANSC domain containing 1
204388_s_atMAOAmonoamine oxidase A
235077_atMEG3maternally expressed 3
229254_atMFSD4major facilitator superfamily domain containing 4
219797_atMGAT4Amannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
204259_atMMP7matrix metallopeptidase 7 (matrilysin, uterine)
227747_atMPZL3myelin protein zero-like 3
204438_atMRC1 /// MRC1L1mannose receptor, C type 1 /// mannose receptor, C type 1-like 1
203037_s_atMTSS1metastasis suppressor 1
212093_s_atMTUS1mitochondrial tumor suppressor 1
213693_s_atMUC1mucin 1, cell surface associated
213375_s_atN4BP2L1NEDD4 binding protein 2-like 1
220184_atNANOGNanog homeobox
209107_x_atNCOA1nuclear receptor coactivator 1
1556057_s_atNEUROD1neurogenic differentiation 1
206915_atNKX2-2NK2 homeobox 2
225911_atNPNTNephronectin
205259_atNR3C2nuclear receptor subfamily 3, group C, member 2
212768_s_atOLFM4olfactomedin 4
203845_atPCAFp300/CBP-associated factor
240317_atPCDHB4protocadherin beta 4
212593_s_atPDCD4programmed cell death 4 (neoplastic transformation inhibitor)
213228_atPDE8Bphosphodiesterase 8B
225207_atPDK4pyruvate dehydrogenase kinase, isozyme 4
205380_atPDZK1PDZ domain containing 1
1553589_a_atPDZK1IP1PDZK1 interacting protein 1
226459_atPIK3AP1phosphoinositide-3-kinase adaptor protein 1
220954_s_atPILRBpaired immunoglobulin-like type 2 receptor beta
219584_atPLA1Aphospholipase A1 member A
206311_s_atPLA2G1Bphospholipase A2, group IB (pancreas)
221529_s_atPLVAPplasmalemma vesicle associated protein
205912_atPNLIPpancreatic lipase
211766_s_atPNLIPRP2pancreatic lipase-related protein 2
208286_x_atPOU5F1(Oct4)POU class 5 homeobox 1 /// POU class 5 homeobox 1B /// POU class 5 homeobox 1 pseudogene 3 /// POU class 5 homeobox 1 pseudogene 4
228469_atPPIDPeptidylprolyl isomerase D (cyclophilin D)
210670_atPPYpancreatic polypeptide
242482_atPRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
227629_atPRLRProlactin receptor
228656_atPROX1prospero homeobox 1
205869_atPRSS1protease, serine, 1 (trypsin 1)
205402_x_atPRSS2protease, serine, 2 (trypsin 2)
213421_x_atPRSS3protease, serine, 3
203317_atPSD4pleckstrin and Sec7 domain containing 4
203029_s_atPTPRN2protein tyrosine phosphatase, receptor type, N polypeptide 2
219562_atRAB26RAB26, member RAS oncogene family
226436_atRASSF4Ras association (RalGDS/AF-6) domain family member 4
223322_atRASSF5Ras association (RalGDS/AF-6) domain family member 5
235638_atRASSF6Ras association (RalGDS/AF-6) domain family member 6
204364_s_atREEP1receptor accessory protein 1
209752_atREG1Aregenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)
205886_atREG1Bregenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)
205815_atREG3Aregenerating islet-derived 3 alpha
1554003_atRGNEFRho-guanine nucleotide exchange factor
219263_atRNF128ring finger protein 128
221614_s_atRPH3ALrabphilin 3A-like (without C2 domains)
213939_s_atRUFY3RUN and FYVE domain containing 3
210592_s_atSAT1spermidine/spermine N1-acetyltransferase 1
203408_s_atSATB1SATB homeobox 1
204035_atSCG2secretogranin II (chromogranin C)
205697_atSCGNsecretagogin, EF-hand calcium binding protein
229620_atSEPP1Selenoprotein P, plasma, 1
202833_s_atSERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
202376_atSERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
209443_atSERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
213572_s_atSERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 1
227627_atSGK3serum/glucocorticoid regulated kinase family, member 3
219256_s_atSH3TC1SH3 domain and tetratricopeptide repeats 1
204019_s_atSH3YL1SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
213464_atSHC2SHC (Src homology 2 domain containing) transforming protein 2
205799_s_atSLC3A1solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
223044_atSLC40A1solute carrier family 40 (iron-regulated transporter), member 1
228221_atSLC44A3solute carrier family 44, member 3
213139_atSNAI2(Slug)snail homolog 2 (Drosophila)
1560228_atSNAI3(Snail)snail homolog 3 (Drosophila)
213721_atSOX2SRY (sex determining region Y)-box 2
200795_atSPARCL1SPARC-like 1 (mast9, hevin)
206239_s_atSPINK1serine peptidase inhibitor, Kazal type 1
213921_atSSTsomatostatin
216905_s_atST14suppression of tumorigenicity 14 (colon carcinoma)
230285_atSVIPsmall VCP/p97-interacting protein
227134_atSYTL1synaptotagmin-like 1
202286_s_atTACSTD2tumor-associated calcium signal transducer 2
205513_atTCN1transcobalamin I (vitamin B12 binding protein, R binder family)
203887_s_atTHBDthrombomodulin
209937_atTM4SF4transmembrane 4 L six family member 4
226403_atTMC4transmembrane channel-like 4
223503_atTMEM163transmembrane protein 163
218345_atTMEM176Atransmembrane protein 176A
220532_s_atTMEM176Btransmembrane protein 176B
200847_s_atTMEM66transmembrane protein 66
202687_s_atTNFSF10tumor necrosis factor (ligand) superfamily, member 10
203824_atTSPAN8tetraspanin 8
229169_atTTC18tetratricopeptide repeat domain 18
209660_atTTRtransthyretin (prealbumin, amyloidosis type I)
231008_atUNC5CLUnc-5 homolog C (C. elegans)-like
226344_atZMAT1zinc finger, matrin type 1
206059_atZNF91zinc finger protein 91